Evidence map›Paper›PMID 41876672›Full record

ArticleScientific reports2026

Age-dependent alterations of TRPA1 and urocortin 1 signaling in the Edinger-Westphal nucleus in a mouse model of Alzheimer's disease.

Antónia Petra Prókay, János Konkoly, Viktória Kormos, Tünde Biró-Sütő, Gábor Kriszta, Helga Panna Szentmártoni, Gergely Berta, Balázs Gaszner, Dóra Zelena, Erika Pintér

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Antónia Petra Prókay *Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
János Konkoly *Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Viktória KormosDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary. viktoria.kormos@aok.pte.hu.
Tünde Biró-SütőDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Gábor KrisztaDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Helga Panna SzentmártoniDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Gergely BertaDepartment of Medical Biology, Medical School, University of Pécs, Pécs, Hungary.
Balázs GasznerDepartment of Anatomy, Medical School, University of Pécs, Pécs, Hungary.
Dóra Zelena *Institute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Erika Pintér *Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholinergic neurons of the preganglionic Edinger-Westphal nucleus (EW) are involved in Alzheimer's disease (AD), however, the role of urocortin 1 (UCN1) positive peptidergic neurons of the centrally projecting EW (EWcp) remains unclear. EWcp cells exclusively express transient receptor potential ankyrin 1 (TRPA1) ion channels, implicated in neurodegenerative disorders. We hypothesized that the EWcp/UCN1/Trpa1 neurons may be involved in AD-related pathologies. Age-dependent (2, 6, 9, 12 and 18 months) Trpa1 mRNA expression (RNAscope in situ hybridization) and UCN1 peptide (immunostaining) content of the EWcp were examined in male triple transgenic mouse (3xTg-AD) model of AD.

Indexed as

Alzheimer DiseaseSignal TransductionTRPA1 Cation ChannelUrocortinsAge FactorsAgingAnimalsDisease Models, AnimalHippocampusMaleMiceMice, TransgenicTRPA1 Cation ChannelTrpa1 protein, mouseUcn1 protein, mouseUrocortinsAgeingAlzheimer’s diseaseDementiaEdinger–Westphal nucleusTRPA1Urocortin 1

Identifiers

PMID41876672
PMCPMC13168636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.