Evidence map›Paper›PMID 41876669›Full record

ArticleGenes and immunity2026

Trub1-mediated pseudouridylation is dispensable for immune cell development and homeostasis.

Vanshika Malviya, Cuong Thi Pham, Lauren Michiels, Laura Seldeslachts, Virginie Marchand, Gerlanda Vella, Laurie Rangan, Yuri Motorin, Greetje Vande Velde, Pierre Lemaitre and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vanshika Malviya *Laboratory of Adaptive Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven-University of Leuven, Leuven, Belgium.
Cuong Thi Pham *Laboratory of Adaptive Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven-University of Leuven, Leuven, Belgium.
Lauren MichielsDepartment of Imaging and Pathology, KU Leuven-University of Leuven, Biomedical MRI, Leuven, Belgium.
Laura SeldeslachtsDepartment of Imaging and Pathology, KU Leuven-University of Leuven, Biomedical MRI, Leuven, Belgium.
Virginie MarchandUniversité de Lorraine, SMP IBSLor EpiRNA-Seq core facility and UMR7365 IMoPA CNRS, Nancy, France.
Gerlanda VellaLaboratory of Tumour Microenvironment and Therapeutic Resistance, Department of Oncology, KU Leuven, VIB-Centre for Cancer Biology, Leuven, Belgium.
Laurie RanganLaboratory of Adaptive Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven-University of Leuven, Leuven, Belgium.
Yuri MotorinUniversité de Lorraine, SMP IBSLor EpiRNA-Seq core facility and UMR7365 IMoPA CNRS, Nancy, France.ORCID 0000-0002-8018-334X
Greetje Vande VeldeDepartment of Imaging and Pathology, KU Leuven-University of Leuven, Biomedical MRI, Leuven, Belgium.
Pierre LemaitreLaboratory of Adaptive Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven-University of Leuven, Leuven, Belgium. pierre.lemaitre@kuleuven.be.
Susan M SchlennerLaboratory of Adaptive Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven-University of Leuven, Leuven, Belgium. susan.schlenner@kuleuven.be.ORCID 0000-0002-8553-3388

Funding

Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1199825NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 11l7525NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G054722NKU Leuven (Katholieke Universiteit Leuven) C14/20/106KU Leuven (Katholieke Universiteit Leuven) STG/16/034
6 · The paper itself

Abstract

Epitranscriptomic modifications are evolutionarily conserved changes to RNA and are present in all RNA types, including mRNA. Next to methylation, pseudouridine is also a prevalent modification found in mRNA and other RNA types. Pseudouridylation of RNA improves RNA stability, RNA stacking and translation fidelity. While m

Indexed as

Intramolecular TransferasesPseudouridineAnimalsB-LymphocytesCell DifferentiationEpitranscriptomeHomeostasisKiller Cells, NaturalMiceRNA, MessengerRNA MethylationT-LymphocytesIntramolecular TransferasesPseudouridinepseudouridine synthasesRNA, Messenger

Identifiers

PMID41876669
PMCPMC13241313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.