Evidence map›Paper›PMID 41876482›Full record

Trial reportNature communications2026

Suppression of pathological oscillations with transcranial focused ultrasound in Parkinson's disease.

John Eraifej, Jake Toth, Jeremy Hanemaaijer, Shenghong He, Xinghao Cheng, Amir Puyan Divanbeighi Zand, Max E Stewart, James J FitzGerald, Christopher R Butler, Timothy Denison and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

John EraifejNuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. john.eraifej@ndcn.ox.ac.uk.ORCID http://orcid.org/0000-0002-2261-0729
Jake TothInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Jeremy HanemaaijerNuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Shenghong HeBrain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5269-1902
Xinghao ChengInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Amir Puyan Divanbeighi ZandNuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3073-2619
Max E StewartNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, UK.
James J FitzGeraldNuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Christopher R ButlerThe George Institute for Global Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7502-9284
Timothy DenisonBrain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Alexander L Green *Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7262-7297
Robin O Cleveland *Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.

Funding

RCUK | Medical Research Council (MRC) MR/X006417/1Rosetrees Trust ID2021\100054
6 · The paper itself

Abstract

Transcranial ultrasound stimulation (TUS) is an emerging method for non-invasive neuromodulation of deep brain structures. However, to date, there is no evidence that TUS can directly modulate disease-related pathological oscillations in the same direction as known therapies. Inspired by clinical deep brain stimulation, in this randomised controlled cross-over study we probed the effects of pallidal TUS pulsed at 130 Hz on subthalamic beta-band activity, a biomarker in Parkinson's Disease (PD) in four male participants with PD. Beta-band power reduced in the ipsilateral subthalamic nucleus (STN) by 10.34% (95% CI:3.81% to 16.87%, p < 0.05, false discovery rate (FDR) adjusted). Beta power reduction was correlated between the ipsilateral (R

Indexed as

Parkinson DiseaseAgedBeta RhythmCross-Over StudiesDeep Brain StimulationHumansHypokinesiaMaleMiddle AgedMotor CortexSubthalamic Nucleus

Identifiers

PMID41876482
PMCPMC13187342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.