Evidence map›Paper›PMID 41876436›Full record

ArticleMagnetic resonance in medicine2026

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer.

James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan and 9 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

James A BanksonDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-8574-154X
Joshua S NiedzielskiDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Collin J HarlanDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-9424-1857
Yunyun ChenDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Christopher M WalkerDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-6381-8737
Philip L LorenziMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Lin TanMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Vikas KundraDepartment of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
Mukundan RagavanDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0001-8678-4229
Dawid SchellingerhoutDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Renjie HeDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Yao DingDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Sahana DatarDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Qing WangDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Christine B PetersonDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Clifton D FullerDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Vlad C SandulacheBobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.
Stephen Y LaiThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Tumor Model and Biospecimen Repository CoreU54CA274321 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jeffrey Nicholas Myers · 2022 to 2026
$7.7M
Leveraging Hyperpolarized MRI for Precision Oncology Approaches in Head and Neck CancerR01CA280980 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BANKSON, JAMES A, LAI, STEPHEN Y · 2022 to 2025
$3.3M
Multi-Site Development & Evaluation of a Quantitative 3D Hyperpolarized C-13 MRI Clinical Prostate Cancer ExamR01CA211150 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BANKSON, JAMES A · 2017 to 2021
$3.2M
Cancer Prevention and Research Institute of Texas RP170366Cancer Prevention and Research Institute of Texas RP210028GE HealthcareNCI NIH HHS P30 CA016672NCI NIH HHS P30CA016672NCI NIH HHS R01 CA211150NCI NIH HHS R01CA211150NCI NIH HHS R01 CA280980NCI NIH HHS R01CA280980NCI NIH HHS U54 CA274321NCI NIH HHS U54CA274321
6 · The paper itself

Abstract

purposeMagnetic resonance imaging using hyperpolarized (HP) [1-

methodsA PK model with two physical compartments and two chemical pools was developed to analyze the conversion of labeled pyruvate into lactate in vitro. Cells exposed to [U-

resultsGood correspondence between complementary quantitative measures of pyruvate metabolism using IC-MS and NMR support the use of this framework as a foundation for quantitative analysis of HP pyruvate metabolism in vitro and in vivo. The three-compartment model identified changes in vascular delivery separately from changes in intracellular pyruvate metabolism, revealed greater heterogeneity in metabolic activity, and identified areas of persistent high metabolic activity against an overall reduction in tumor metabolism after 8 days of treatment.

conclusionThis framework for analysis provides a validated approach and demonstrates feasibility for quantitative evaluation of HP pyruvate metabolism in vivo.

Indexed as

Magnetic Resonance ImagingPyruvic AcidThyroid NeoplasmsCarbon IsotopesHumansMagnetic Resonance SpectroscopyCarbon IsotopesPyruvic Acidcancer metabolismhyperpolarized pyruvatepharmacokinetic analysisquantitative imaging

Identifiers

PMID41876436
PMCPMC13269194

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.