ArticleJMIR research protocols2026
Efficacy of Nutritional Interventions in Adult Poststroke Rehabilitation: Protocol for a Systematic Review and Trial Sequential Meta-Analysis.
Article in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Malnutrition is a prevalent and serious concern in adult survivors of stroke, often worsening their clinical status and leading to a poor prognosis. However, the effectiveness of nutritional interventions in this population remains uncertain. Furthermore, the impact of nutritional support on functional recovery, especially in relation to rehabilitation outcomes, has not been sufficiently investigated. Objective: This meta-analysis aims to synthesize evidence from existing randomized controlled trials (RCTs) to determine whether nutrient supplements confer measurable benefits in poststroke rehabilitation, with overall mortality as the primary outcome and multiple relevant indicators as secondary outcomes. Methods: RCTs that compare nutrient supplements and a standard diet or placebo supplements in adult survivors of stroke will be included. Literature searches will be conducted in the PubMed, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang, and Cochrane Library databases. Two reviewers will independently perform the processes of literature retrieval, screening, data extraction, and assessment of risk of bias. Risk of bias in included studies will be evaluated using the revised Cochrane risk-of-bias tool for RCTs. Review Manager will be used for data pooling. Subgroup analysis, trial sequential analysis, and sensitivity analysis will be conducted. Results: This study was funded in 2023 (2023ZDFC0301) and registered in PROSPERO (CRD420251028426) prior to initiation. As of November 25, 2025, literature screening has not yet started. The planned timeline is as follows: complete literature screening by February 28, 2026; finalize full-text assessment and data extraction by May 30, 2026; conclude trial sequential analysis by June 30, 2026; and complete manuscript preparation for publication by July 30, 2026. Conclusions: This systematic review and meta-analysis will provide evidence for the efficacy of nutritional interventions in adult poststroke rehabilitation, which may inform clinical guidelines and optimize rehabilitation strategies for this vulnerable population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.