Evidence map›Paper›PMID 41876090›Full record

Observational studyBJOG : an international journal of obstetrics and gynaecology2026

Impaired Hearing and Systolic Blood Pressure as Potential Markers of Cerebral Infarction After Eclampsia: A Cross-Sectional Study.

Lina Bergman, Henrik Imberg, Eduard Langenegger, Ashley Moodley, Richard Pitcher, Stephanie Griffith-Richards, Karl Bergman, Roxanne Hastie, Stephen Tong, Susan P Walker and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lina BergmanDepartment of Obstetrics and Gynecology, Stellenbosch University, Cape Town, South Africa.
Henrik ImbergDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Eduard LangeneggerDepartment of Obstetrics and Gynecology, Stellenbosch University, Cape Town, South Africa.
Ashley MoodleyDepartment of Obstetrics and Gynecology, Stellenbosch University, Cape Town, South Africa.
Richard PitcherDivision of Radiodiagnosis, Stellenbosch University, Cape Town, South Africa.
Stephanie Griffith-RichardsDivision of Radiodiagnosis, Stellenbosch University, Cape Town, South Africa.
Karl BergmanDepartment of Medicine, Institute of Clinical and Molecular Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Roxanne HastieDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Stephen TongTranslational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.
Susan P WalkerTranslational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.
Johan WikströmDepartment of Surgical Sciences, Neuroradiology, Uppsala University, Uppsala, Sweden.
Catherine CluverDepartment of Obstetrics and Gynecology, Stellenbosch University, Cape Town, South Africa.

Funding

Centrum fÖr Klinisk Forskning DalarnaJane och Dan Olssons StiftelseMärta Lundqvists StiftelseMercy PerinatalPreeclampsia FoundationSvenska LäkaresällskapetSwedish Foundation for International Cooperation in Research and Higher EducationVetenskapsrådetWallenberg Centre for Molecular and Translational Medicine
6 · The paper itself

Abstract

objectiveEclampsia is associated with short- and long-term neurological deficits. Identifying which women may be at risk is important. Magnetic resonance imaging shows an incidence of 30%-40% of subclinical cerebral infarcts among women with eclampsia. A simple screening tool would be useful to identify at-risk women. The objective of this study was to explore clinical markers to identify women at highest risk for silent cerebral infarcts in women who have experienced eclampsia.

designThis was a prospective observational study with cross-sectional MRI ascertainment conducted at Tygerberg Hospital, a tertiary referral centre in Cape Town, South Africa. Women were prospectively assessed for symptoms and signs known to be associated with eclampsia. Cerebral infarcts were identified using brain magnetic resonance imaging. Associations between clinical variables and the presence of cerebral infarcts were evaluated using logistic regression, with variables significant at the 20% level considered for inclusion in multivariable analyses using stepwise selection.

resultsA total of 49 women with eclampsia were included in the analysis, of whom 33% (n = 16) had cerebral infarcts detected on MRI. Highest systolic blood pressure and impaired hearing prior to the eclamptic seizure were the clinical variables most strongly associated with the presence of silent cerebral infarcts, with an area under the receiver operating characteristic curve of 0.72 (95% CI 0.56-0.88). At a risk threshold of 43%, sensitivity was 60% (95% CI 36%-80%) and specificity was 84% (95% CI 67%-93%).

conclusionsHigher systolic blood pressure and impaired hearing were the clinical features most strongly associated with silent cerebral infarcts in women with eclampsia. These findings highlight potentially useful clinical markers that, following external validation, may support triage decisions regarding neuroimaging and neurological follow up.

Indexed as

Blood PressureCerebral InfarctionEclampsiaHearing LossAdultBiomarkersCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingPregnancyProspective StudiesRisk FactorsSouth AfricaBiomarkerscerebral infarctsclinical markerseclampsiamagnetic resonance imaging

Identifiers

PMID41876090
PMCPMC13254043

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.