ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2026
Persistent exposure to second-hand smoke and asthma endotypes in a study of Puerto Rican youth.
Yueh-Ying Han, Molin Yue, Kimberly Pereira, Franziska J Rosser, Kristina Gaietto, Wei Chen, Juan C Celedón
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In one paragraphArticle in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Yueh-Ying HanDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Molin YueDepartment of Biostatistics and Health Data Science, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kimberly PereiraDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Franziska J RosserDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kristina GaiettoDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Wei ChenDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: juan.celedon@chp.edu.
Funding
Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8MGenes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8MExposure to violence during childhood and Th2-high asthma in young Puerto Rican adultsR01HL168539 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Juan Carlos Celedon · 2023 to 2026
$2.6MChronic outdoor air pollution, airway epithelial "omics" and asthma exacerbations in childrenK08HL159333 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSSER, FRANZISKA · 2021 to 2024
$641kT-helper 2-low pediatric asthma endotypes: omics, biomarkers, and clinical characteristicsK08HL177170 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kristina Gaietto · 2025 to 2026
$324kNHLBI NIH HHS K08 HL159333NHLBI NIH HHS K08 HL177170NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL117191NHLBI NIH HHS R01 HL168539
6 · The paper itselfAbstract
backgroundLittle is known about second-hand smoke (SHS) exposure and asthma endotypes in children and adolescents.
objectiveTo evaluate the relation between exposure to SHS and asthma endotypes in Puerto Rican youth.
methodsLongitudinal study of 337 Puerto Rican youths with (n = 173) and without (n = 164) asthma who completed a first visit at ages 6 to 14 years and a second visit at ages 9 to 20 years. Exposure to SHS was defined as: in early life only, at school age only (at either study visit only), and persistent (in early life and at school age). On the basis of nasal epithelial expression of 8 "signature genes" for T
resultsIn a multivariable analysis, youths with persistent SHS exposure had 2.2 times higher odds of T
conclusionIn Puerto Rican youths, persistent SHS exposure was associated with T
Indexed as
AsthmaTh17 CellsTh2 CellsTobacco Smoke PollutionAdolescentChildEnvironmental ExposureFemaleHumansLongitudinal StudiesMalePuerto RicoYoung AdultTobacco Smoke Pollution
Identifiers
PMID41876062
PMCPMC13170493
What OpenQuestion holds
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LicenceTDM
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