Evidence map›Paper›PMID 41875877›Full record

ArticleCurrent biology : CB2026

Big1 is a cell-cycle regulator linking cell size to basal body number in Tetrahymena thermophila.

Alexander J Stemm-Wolf, Adam W J Soh, Lisa E Mitchell, Huangqingbo Sun, Erik Collet, Gayatri L Dholakia, Vikram Raju, Jay R Hesselberth, J Matthew Taliaferro, Robert F Murphy and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Molecular biology of the cell · 2026
    Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alexander J Stemm-WolfDepartment of Cell and Developmental Biology, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Adam W J SohDepartment of Cell and Developmental Biology, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Lisa E MitchellDepartment of Cell and Developmental Biology, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Huangqingbo SunRay and Stephanie Lane Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave., Pittsburgh, PA 15213, USA.
Erik ColletDepartment of Cell and Developmental Biology, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Gayatri L DholakiaDepartment of Cell and Developmental Biology, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Vikram RajuDepartment of Cell and Developmental Biology, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Jay R HesselberthDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA; RNA Bioscience Initiative, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
J Matthew TaliaferroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA; RNA Bioscience Initiative, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Robert F MurphyRay and Stephanie Lane Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave., Pittsburgh, PA 15213, USA.
Lydia R HeasleyDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA.
Chad G PearsonDepartment of Cell and Developmental Biology, University of Colorado Anschutz, 12801 E 17th Ave., Aurora, CO 80045, USA. Electronic address: chad.pearson@cuanschutz.edu.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3M
Nanopore analysis of transfer RNA forms and functionsR35GM119550 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jay R Hesselberth · 2016 to 2026
$4.5M
Centriole assembly and function for centrosome and cilia biologyR35GM140813 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI CHAD G PEARSON · 2021 to 2026
$3.5M
Understanding the regulatory language of RNA localizationR35GM133385 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jefferson Matthew Taliaferro · 2019 to 2026
$3.4M
Properties and mechanisms of punctuated genome instabilityR00GM134193 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI HEASLEY, LYDIA RENE · 2022 to 2024
$747k
NCI NIH HHS P30 CA046934NIGMS NIH HHS P41 GM103712NIGMS NIH HHS R00 GM134193NIGMS NIH HHS R35 GM119550NIGMS NIH HHS R35 GM133385NIGMS NIH HHS R35 GM140813
6 · The paper itself

Abstract

Cell-size control is necessary for the optimum function and fitness of cells. In many eukaryotes, cell size is controlled through the initiation of cell division once a size threshold is achieved.

Indexed as

Basal BodiesCell CycleCell Cycle ProteinsCell SizeProtozoan ProteinsTetrahymena thermophilaCell Cycle ProteinsProtozoan Proteinsbasal bodycell cyclecell sizeTetrahymena thermophila

Identifiers

PMID41875877
PMCPMC13014017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.