ArticleNano letters2026
High-Curvature Features Improve Targeting of Nanoconstructs with Small-Molecule Ligands.
Article in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Small molecules are promising ligands because of their affinity for cancer targets, chemical stability, controlled synthesis, and ease of characterization. Under biological conditions, small-molecule ligands grafted to nanoconstructs become coated with nonspecific proteins, collectively known as a protein corona, which physically obstruct targeting interactions because of their orders of magnitude difference in size. Here, we investigated how nanoparticle shape affects folic-acid ligand (FA) binding to folate receptors on cancer cell membranes using ensemble and single-particle analysis. From dot blot assays, we determined that gold nanoconstructs with spiky cores (tip features < 5 nm) and FA ligands bind more folate receptors compared to spherical cores of similar surface areas. Single-nanoconstruct tracking showed a higher proportion of spiky constructs displayed confined motion, which we attributed to binding of folate receptors. Our findings reveal that nanoparticles with anisotropic nanofeatures can circumvent adverse protein corona effects and enhance targeting of nanoconstructs with small-molecule ligands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.