Evidence map›Paper›PMID 41875165›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Inorganic phosphate and the rapid mobilization of metabolic energy in neurons.

Paul C Rosen, Shivang Sullere, Panhui Fu, Juan R Martínez-François, Daniel J Brooks, Erica Kim, Chenghua Gu, Gary Yellen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul C RosenDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-7414-454X
Shivang SullereDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Panhui FuDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Juan R Martínez-FrançoisDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Daniel J BrooksDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.ORCID 0009-0004-7527-242X
Erica KimDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.ORCID 0009-0003-8025-6152
Chenghua GuDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Gary YellenDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0003-4228-7866

Funding

High-throughput optimization of genetically-encoded fluorescent biosensorsR01GM124038 · NIGMS · HARVARD MEDICAL SCHOOL · PI YELLEN, GARY I · 2017 to 2025
$2.5M
Mechanisms of Seizure Resistance in a Mouse Genetic Model with Altered MetabolismR37NS102586 · NINDS · HARVARD MEDICAL SCHOOL · PI GARY I YELLEN · 2023 to 2026
$1.7M
Understanding Compartmentalized Leucine Metabolism Downstream of mTORC1 SignalingF31CA254162 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ROSEN, PAUL · 2020 to 2023
$186k
Brain and Behavior Research Foundation (BBRF) Young Investigator GrantDepartment of Neurobiology, Harvard Medical School Alice and Joseph Brooks Fund Postdoctoral FellowshipDepartment of Neurobiology, Harvard Medical School Edward R. and Anne G. Lefler Center Postdoctoral FellowshipDepartment of Neurobiology, Harvard Medical School Stuart H. Q. and Victoria Quan FellowshipHHMI (HHMI) InvestigatorJane Coffin Childs Memorial Fund for Medical Research (JCC) HHMI FellowshipNCI NIH HHS F31 CA254162NIGMS NIH HHS R01 GM124038NINDS NIH HHS R37 NS102586
6 · The paper itself

Abstract

Neurons experience brief, intense periods of energy demand when they are excited, but how they rapidly coordinate energy expenditure with production is incompletely understood. Part of the difficulty has been measuring the levels of molecules involved in this metabolic response with spatiotemporal precision in single live cells. Here, we engineered a quantitative fluorescent biosensor to monitor cytosolic inorganic phosphate (P

Indexed as

Energy MetabolismNeuronsPhosphatesAnimalsBiosensing TechniquesGlycolysisMicePhosphatesfluorescence lifetime imagingfluorescent biosensors of metabolismglycolytic regulationneuronal energy metabolism

Identifiers

PMID41875165
PMCPMC13014856

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.