ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026
Improvement of glucose homeostasis during leptin treatment does not alter the intestinal microbiome in male diabetic UC Davis type-2 diabetes mellitus rats.
Manuel Martínez-Ruiz, Leslie Tabor-Simecka, James L Graham, Christopher Randolph, Renee Fox, Renny Lan, Lindsay Pack, Tanya LeRoith, Kimber L Stanhope, Laxmi Yeruva and 2 more
Abstract read
In one paragraphArticle in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Leslie Tabor-SimeckaArkansas Children's Nutrition Center, Little Rock, Arkansas, United States.
James L GrahamDepartment of Molecular Biosciences, School of Veterinary Medicine, UC Davis, California, United States.ORCID 0000-0001-6507-8149 Christopher RandolphArkansas Children's Research Institute, Little Rock, Arkansas, United States.
Tanya LeRoithDepartment of Biomedical Science and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States.
Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine, UC Davis, California, United States.
Laxmi YeruvaUSDA-ARS, Microbiome and Metabolism Research Unit, Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States.ORCID 0000-0003-4289-9109 Peter J HavelDepartment of Molecular Biosciences, School of Veterinary Medicine, UC Davis, California, United States.
Funding
Expanding Translational Science in ArkansasUM1TR004909 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI Laura P James · 2024 to 2026
$11.7MThe National Center for Metabolic Phenotyping of Mouse Models of Obesity and Diabetes (MPMOD) at UC DavisU2CDK135074 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2023 to 2026
$4.0MNeuropathology and inflammation in a nonhuman primate model of insulin resistance/metabolic syndromeR01AG085572 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STEPHEN D GINSBERG, PETER J HAVEL · 2024 to 2026
$3.8MCTSA K12 Program at the University of Arkansas for Medical SciencesK12TR004924 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI Jason Eli Farrar, Joshua Kennedy · 2024 to 2026
$2.3MHHS | NIH | National Center for Advancing Translational Sciences (NCATS) 1K12TR004924HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UM1TR004909HHS | NIH | National Institute on Aging (NIA) R01AG085572HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) U24DK135074NCATS NIH HHS K12 TR004924NCATS NIH HHS UM1 TR004909NIA NIH HHS R01 AG085572NIDDK NIH HHS U2C DK135074USDA | Agricultural Research Service (ARS) 6026-10700-001-00D
6 · The paper itselfAbstract
Gut dysbiosis contributes to type 2 diabetes mellitus (T2DM) progression according to the preclinical evidence. Alterations in gut microbiome, energy metabolism, and barrier function were observed in individuals with obesity and insulin resistance. However, it remains unclear whether therapeutic interventions can reverse these alterations. This study aimed to evaluate whether improvements of glucose homeostasis resulting from leptin administration can lead to changes in colonic epithelial metabolism and barrier function in male UC Davis type 2 diabetic mellitus (UCD-T2DM) rats. Male UCD-T2DM rats (age: 173 ± 41 days) with 6 wk postonset of diabetes were randomized to receive daily subcutaneous injections of either phosphate buffer solution (control;
Indexed as
Blood GlucoseColonDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Gastrointestinal MicrobiomeGlucoseLeptinAnimalsHomeostasisInsulin ResistanceIntestinal Barrier FunctionIntestinal MucosaMaleRatsBlood GlucoseGlucoseLeptindiabetes mellitusglucose homeostasisgut permeabilityinsulin sensitivitymicrobiome
Identifiers
PMID41875058
PMCPMC13104595
What OpenQuestion holds
Textmetadata
LicenceTDM
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