ArticleCerebral cortex (New York, N.Y. : 1991)2026
Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.
Article in Cerebral cortex (New York, N.Y. : 1991), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- A high-dimensional atlas of parvalbumin interneuron soma morphology in mouse visual and somatosensory cortex.Frontiers in neuroscience · 2026Article
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Abstract
Corticothalamic layer 6 modulates information flow between cortical and thalamic circuits. Previous research reported contrasting inhibitory or excitatory effects of corticothalamic layer 6 on cortical dynamics, potentially reflecting technological discrepancies or physiological differences in corticothalamic layer 6 function. To resolve these discrepancies, we combined translaminar, multi-channel in vivo electrophysiology in the primary somatosensory cortex of anesthetized mice with optogenetic stimulation across a range of stimulation regimes to manipulate firing rate and spiking statistics of corticothalamic layer 6. Increasing corticothalamic layer 6 firing rates exerted a transition from inhibition to excitation across cortical layers. Furthermore, corticothalamic layer 6 activity imparted population synchrony onto distinct cortical subpopulations, independent of changes in overall corticothalamic layer 6 activity. In the thalamus, corticothalamic layer 6 modulated thalamic bursting in a bidirectional manner, dependent on optogenetic stimulation frequency. These results demonstrate that corticothalamic layer 6 in primary somatosensory cortex can bidirectionally modulate both cortical firing and thalamic firing mode, elucidating a more nuanced function of somatosensory corticothalamic layer 6 in thalamic and cortical signaling than previously recognized.
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