Evidence map›Paper›PMID 41874875›Full record

ArticleAnnals of surgical oncology2026

Colloid Carcinoma of the Pancreas: A Distinct and Less Aggressive Entity in the Spectrum of Pancreatic Malignancies.

Maria Imperatrice, M Lisa Zhang, Motaz Qadan, Peter J Fagenholz, Avinash Kambadakone, Shravya Srinivas Rao, Yasmin G Hernandez-Barco, Andrew L Warshaw, Keith D Lillemoe, Andrew S Liss and 2 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria ImperatriceDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
M Lisa ZhangDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Motaz QadanDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Peter J FagenholzDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Avinash KambadakoneDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Shravya Srinivas RaoDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yasmin G Hernandez-BarcoDepartment of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Andrew L WarshawDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Keith D LillemoeDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Andrew S LissDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mari Mino-KenudsonDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Carlos Fernández-Del CastilloDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. CFERNANDEZ@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic colloid carcinoma (CC) is a rare subtype of invasive carcinoma arising from intraductal papillary mucinous neoplasm (IPMN), characterized by abundant extracellular mucin and an intestinal phenotype. Its rarity (1-3% of pancreatic cancers) and inclusion in heterogeneous cohorts have limited a clear definition of its behavior. This study aimed to characterize CC and compare it with IPMN-derived tubular carcinoma (TC). PATIENTS AND

methodsPatients resected for an IPMN at a single institution (1990-2025) were identified. A subset of 50 CC and 145 TC cases was selected. Demographic, clinical, radiological, pathological, and outcome data were analyzed.

resultsCC accounted for 25% of invasive IPMN. Patients with CC were more often male (70% versus 41%) and had higher rates of steatorrhea (26% versus 3%), diabetes (44% versus 27%), and pancreatitis (36% versus 17%) compared with TC (all p < 0.05). Most tumors arose in the head (64%) and showed high-risk stigmata (94%). Nearly all CC displayed intestinal differentiation and main duct involvement (98% each). Compared with TC, CC was often node-negative (80% versus 57%, p < 0.01), with less perineural (28% versus 58%, p < 0.001) and vascular invasion (6% versus 26%, p = 0.002). CC was associated with significantly longer median overall survival (69 versus 31 months, p = 0.02). Recurrence was uncommon (5-year RFS 58%) and predominantly distant (80%), with distinct patterns including bone metastases (19%) and pseudomyxoma peritonei (8%).

conclusionsColloid carcinoma is a distinct subtype of invasive IPMN with indolent behavior. Recognition of its unique features may refine prognostic stratification and guide tailored management.

Indexed as

Adenocarcinoma, MucinousCarcinoma, Pancreatic DuctalPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessPrognosisRetrospective StudiesSurvival RateColloid carcinomaIntraductal papillary mucinous neoplasm (IPMN)MucinSurvival analysis

Identifiers

PMID41874875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.