Evidence map›Paper›PMID 41874812›Full record

ArticlePflugers Archiv : European journal of physiology2026

Nitrergic neurotransmission within the lateral hypothalamus modulates cardiovascular responses to stress in rats.

Gabriela A Silva, Lilian L Reis-Silva, Lucas Gomes-de-Souza, Lígia R R Tavares, Lucas Barretto-de-Souza, Vinícius Pelarin, Carlos C Crestani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabriela A Silva *Laboratory of Pharmacology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville, Araraquara, SP, 14800-903, Brazil.
Lilian L Reis-Silva *Laboratory of Pharmacology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville, Araraquara, SP, 14800-903, Brazil.
Lucas Gomes-de-SouzaLaboratory of Pharmacology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville, Araraquara, SP, 14800-903, Brazil.
Lígia R R TavaresLaboratory of Pharmacology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville, Araraquara, SP, 14800-903, Brazil.
Lucas Barretto-de-SouzaLaboratory of Pharmacology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville, Araraquara, SP, 14800-903, Brazil.
Vinícius PelarinLaboratory of Pharmacology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville, Araraquara, SP, 14800-903, Brazil.
Carlos C CrestaniLaboratory of Pharmacology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville, Araraquara, SP, 14800-903, Brazil. carlos.crestani@unesp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lateral hypothalamus (LH) is a key brain region involved in integrating cardiovascular and autonomic components of the stress response, yet the local neurochemical mechanisms governing these functions remain poorly understood. This study examined the contribution of nitrergic neurotransmission within the LH to cardiovascular adjustments induced by acute restraint stress in rats. To this end, animals received bilateral microinjections into the LH of either the nonselective nitric oxide synthase (NOS) inhibitor L-NAME, the selective neuronal NOS (nNOS) inhibitor N

Indexed as

Hypothalamic Area, LateralNitric OxideStress, PsychologicalSynaptic TransmissionAnimalsArginineBlood PressureEnzyme InhibitorsHeart RateMaleNG-Nitroarginine Methyl EsterNitric Oxide DonorsNitric Oxide Synthase Type INitric Oxide Synthase Type IIRatsRats, WistarArginineEnzyme InhibitorsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide DonorsNitric Oxide Synthase Type INitric Oxide Synthase Type IIN(omega)-propylarginineBlood pressureHeart rateNeuronal nitric oxide synthaseRestraint stressSympathetic activity

Identifiers

PMID41874812
PMCPMC13013230

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.