ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2026
Interleukin-6 to identify mildly injured patients in the trauma resuscitation room - a clinical feasibility study.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Older age and post-traumatic organ failure a TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
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9 authors.
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Abstract
purposeOvertriage in the trauma resuscitation room (TRR) is often a consequence of admission based solely on trauma mechanism criteria. As interleukin-6 (IL-6) can assess injury severity in critically injured patients, the hypothesis of this study was that IL-6 can differentiate upon admission between mild (Injury Severity Score (ISS) 0-8) and moderate (ISS 9-15) trauma and that the parameter correlates with injury severity in lower injury severity groups (ISS < 16) during the first 24 h. Subsequently, we evaluated the ability to define IL-6 cut-off values with an adequate sensitivity, specificity, and negative predictive value to distinguish between moderate and mild injuries.
methodsFifty patients admitted to the TRR solely based on trauma mechanism criteria and with an ISS < 16 were included in the study. IL-6 was measured at admission, 1, 6, 12 and 24 h later.
resultsThirty-one patients were mildly injured (ISS 0-8), while nineteen patients sustained moderate injuries (ISS 9-15). IL-6 correlated significantly with ISS at all time points. Moderately injured patients showed significantly higher IL-6 levels than mildly injured patients during the first 6 h. IL-6 levels at admission predicted moderate injuries for the IL-6 cut-off value of 2.9pg/ml with a sensitivity of 0.933, specificity of 0.370 and a negative predictive value of 0.970 resulting in undertriage rates of 6.6% and overtriage rates of 54.8%.
conclusionThe data of this feasibility study indicates that IL-6 has the potential to be employed in clinical workflows for early determination between patients with mild and moderate injuries, who are admitted to TRR based on trauma mechanism criteria to abort as early as possible TRR treatment and therefore free resources immediately while preserving patients' safety.
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