Evidence map›Paper›PMID 41874610›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

From gastric to neuroprotection: pantoprazole mitigates epilepsy via TrkB/BDNF and KCC2 modulation.

Arya Kuhu Vishwapriya, Kamini Verma, Garima Sharma, Nitika Sindhu, Swati Paliwal, Smita Jain, Jaya Dwivedi, Sarvesh Paliwal, Swapnil Sharma

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Arya Kuhu VishwapriyaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
Kamini VermaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
Garima SharmaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
Nitika SindhuDepartment of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
Swati PaliwalDepartment of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
Smita JainSchool of Pharmacy & Technology Management, SVKM's NMIMS, Shirpur, 425405, Maharashtra, India.
Jaya DwivediDepartment of Chemistry, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
Sarvesh PaliwalDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
Swapnil SharmaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India. skspharmacology@gmail.com.ORCID http://orcid.org/0000-0003-2639-7096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is generally described as a pathology resulting from an imbalance between excitatory and inhibitory activities. In recent years, neurotrophins have been recognized as key players in the pathophysiology of nervous system diseases. One such neurotrophin, BDNF, and its receptor, TrkB, play critical roles as epileptogenic factors that regulate neuronal hyperexcitability and synaptic plasticity. In this study, we sought to elucidate the exact mechanisms underlying the neuroprotective and antiepileptic effects of pantoprazole. The molecular docking study indicated key interactions of pantoprazole with the TrkB receptor (PDB ID: 4AT3). Furthermore, pantoprazole exhibited notable in vitro TrkB kinase inhibitory activity (IC

Indexed as

AnticonvulsantsBrain-Derived Neurotrophic FactorEpilepsyMembrane GlycoproteinsNeuroprotective AgentsPantoprazoleReceptor, trkBSymportersAnimalsCell Line, TumorCell SurvivalDisease Models, AnimalHumansK Cl- CotransportersMaleMiceAnticonvulsantsBdnf protein, mouseBrain-Derived Neurotrophic FactorK Cl- CotransportersMembrane GlycoproteinsNeuroprotective AgentsNtrk2 protein, mousePantoprazolePentylenetetrazoleProtein-Tyrosine KinasesReceptor, trkBSymporterstropomyosin-related kinase-B, humanBrain-derived neurotrophic factorEpilepsyPantoprazolePotassium-chloride co-transporter 2Receptor tyrosine kinase-B

Identifiers

PMID41874610

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