Evidence map›Paper›PMID 41874488›Full record

ArticleJACC. Case reports2026

VF Arrest at Rest in a Teenager With Anomalous Origin of Coronaries and DSG2 Variant.

Ahmad Abdulkader, Redmond Burke, Kara Gay Simon, Ryan Halickman, Anthony Rossi, Parul Jayakar, Alvarado Burgos, Melissa Olen, Utkarsh Kohli

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PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Ahmad AbdulkaderDivision of Pediatric Cardiology, Nicklaus Children's Hospital, Miami, Florida, USA.
Redmond BurkeDepartment of Cardiovascular and Thoracic Surgery, Nicklaus Children's Hospital, Miami, Florida, USA.
Kara Gay SimonDivision of Pediatric Cardiology, Nicklaus Children's Hospital, Miami, Florida, USA.
Ryan HalickmanDivision of Pediatric Cardiology, Nicklaus Children's Hospital, Miami, Florida, USA.
Anthony RossiDivision of Pediatric Cardiology, Nicklaus Children's Hospital, Miami, Florida, USA; Professor of Pediatrics, Florida International University Herbert Wertheim College of Medicine, Miami, Florida, USA.
Parul JayakarDepartment of Genetics, Nicklaus Children's Hospital, Miami, Florida, USA.
Alvarado BurgosDepartment of Radiology, Nicklaus Children's Hospital, Miami, Florida, USA.
Melissa OlenDivision of Pediatric Cardiology, Nicklaus Children's Hospital, Miami, Florida, USA.
Utkarsh KohliDivision of Pediatric Cardiology, Nicklaus Children's Hospital, Miami, Florida, USA; Professor of Pediatrics, Florida International University Herbert Wertheim College of Medicine, Miami, Florida, USA. Electronic address: utkarsh.kohli@Nicklaushealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSudden cardiac arrest (SCA) in adolescents is rare and often attributed to genetic or structural cardiac abnormalities. The differentials remain broad including anomalous aortic origin of a coronary artery (AAOCA). CASE SUMMARY: A 16-year-old male experienced ventricular fibrillation arrest at rest. Imaging revealed anomalous aortic origin of the right and left coronary arteries (AAOCA) with high-risk features. Genetic testing identified a sequence variation in DSG2. The patient underwent surgical unroofing and was discharged with a wearable cardioverter-defibrillator. A subcutaneous defibrillator was implanted 8 weeks later. The patient remains well without further events. DISCUSSION: This case highlights the diagnostic complexity when rare structural and potential genetic etiologies coexist, especially in the context of SCA at rest. The literature supports advanced imaging, surgical correction for AAOCA, and comprehensive genetic evaluation in pediatric SCA at rest.

Indexed as

anomalous coronariesDSG2 sequence variationsudden cardiac arrestventricular fibrillation

Identifiers

PMID41874488
PMCPMC13130907

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