ArticleJACC. Case reports2026
Colchicine-Responsive Dacron Hypersensitivity After Bentall Procedure: A Rare Trigger of Diffuse Coronary Artery Disease.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBentall operation with Dacron material can lead to increased risk for cardiovascular events in a distant organ through inflammation and immune-mediated reaction. CASE SUMMARY: A 56-year-old man who had undergone a Bentall procedure with Dacron graft presented with suspicion of acute coronary syndrome 3 months later. Coronary angiography revealed extensive fibrotic process throughout all coronary arteries rather than thrombi. His eosinophil count was higher at the emergency service than in the preoperative state. Eosinophil count gradually decreased with oral corticosteroid and colchicine treatment. DISCUSSION: Our patient demonstrated a Dacron patch-triggered reaction in diffuse coronary artery disease, characterized by inflammation and immune-mediated mechanisms, leading to an elevated eosinophil count. Colchicine and oral corticosteroids can overcome eosinophilic reaction driven by Dacron graft in distant organs. Monitoring eosinophil counts can serve as an effective measure to assess the treatment response to colchicine during follow-up assessments. TAKE-HOME MESSAGES: Diffuse fibrotic thickening throughout the coronary arteries after a Bentall procedure may be caused by eosinophilic inflammation. Colchicine and oral corticosteroids may suppress the eosinophilic inflammation induced by the Dacron graft in distant organs. Eosinophil count may be monitored for the therapeutic response of long-term colchicine usage.
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