Evidence map›Paper›PMID 41874464›Full record

ArticleAging cell2026

Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation.

Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc and 8 more

Abstract read
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Evelyn OceguedaDepartment of Health Sciences and Nutrition, Merrimack College, North Andover, Massachusetts, USA.
Gabrielle ChaseDepartment of Natural Sciences, Merrimack College, North Andover, Massachusetts, USA.
Michaella NiceforoDepartment of Natural Sciences, Merrimack College, North Andover, Massachusetts, USA.
Aida JavidanDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Lydia GugliuzzaDepartment of Natural Sciences, Merrimack College, North Andover, Massachusetts, USA.
Jingting YuRazavi Newman Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, California, USA.
Rachel Y KangDepartment of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Ava LankowskiDepartment of Health Sciences and Nutrition, Merrimack College, North Andover, Massachusetts, USA.
Olivia StefanikDepartment of Health Sciences and Nutrition, Merrimack College, North Andover, Massachusetts, USA.
Kailey LeclercDepartment of Natural Sciences, Merrimack College, North Andover, Massachusetts, USA.
Yolander ValentineDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Micah J DrummondDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah, USA.
Jude T DeeneyDepartment of Endocrinology, Diabetes, Nutrition & Weight Management, Boston University School of Medicine, Boston, Massachusetts, USA.
Josephine S Modica-NapolitanoDepartment of Natural Sciences, Merrimack College, North Andover, Massachusetts, USA.
Elizabeth A ProctorDepartment of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Hatice HasturkADA Forsyth Institute, Somerville, Massachusetts, USA.ORCID 0000-0002-4395-3958
Barbara S NikolajczykDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Leena P BharathDepartment of Health Sciences and Nutrition, Merrimack College, North Andover, Massachusetts, USA.

Funding

San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
Regulation of macrophage metabolism in aged muscle during recoveryR01AG076075 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Micah J Drummond, Ryan M O'Connell · 2022 to 2026
$3.3M
Mitochondrial Aging Promotes InflammationR15AG068957 · NIA · MERRIMACK COLLEGE · PI PANNEERSEELAN-BHARATH, LEENA · 2021 to 2025
$868k
NIA NIH HHS P30 AG068635NIA NIH HHS R01 AG076075NIA NIH HHS R15 AG068957NIA NIH HHS R15AG068957NIH HHS P30AG068635NIH HHS R01AG076075NIH HHS R01AG084180,R01AG079525,R01AG072513NIH HHS R56AG06985
6 · The paper itself

Abstract

Age-related cellular changes negatively impact CD4

Indexed as

AgingInflammationSuccinate DehydrogenaseTh17 CellsAdultAgedAged, 80 and overCytokinesFemaleHumansMaleMiddle AgedMitochondriaCytokinesSuccinate DehydrogenaseAgingComplex IICytokinesMitochondriaSDHT cellsTh17 cytokines

Identifiers

PMID41874464
PMCPMC13140695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.