ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Halofuginone is a Molecular Glue Degrader of Integrin β4.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Integrin β4 (gene name: ITGB4) overexpression is associated with aggressive phenotypes and poor prognosis across multiple solid tumors. Despite its clinical significance, therapeutic strategies targeting integrin β4 remain underdeveloped. Targeted protein degradation technology, particularly molecular glue degraders, offer a promising approach for eliminating oncoproteins. However, the serendipitous discovery of molecular glues and limited exploration of substrate receptor have largely hindered the rational development of molecular glue degraders. In this study, through high throughput screening from a natural product library, we identified halofuginone (HF) as a potential molecular glue that promotes integrin β4 degradation via the CRL4B
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