ArticleFEMS microbiology letters2026
A new component of the DNA damage response biofilm axis in Acinetobacter baumannii is a TetR-like DNA damage response regulator.
Article in FEMS microbiology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Should I stay or should I go? DNA damage thresholds drive stay-or-go decisions inJournal of bacteriology · 2026Review
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6 authors.
Funding
Abstract
Acinetobacter baumannii is an opportunistic pathogen that employs a variety of strategies to evade antibiotic treatment which include forming biofilms, which are protective bacterial multicellular communities. Previously, we demonstrated RecA, a key component of the DNA damage response (DDR), governs biofilms with RecA levels inversely correlated with biofilm formation, such that low RecA levels results in high biofilms. In this study, we identify another DDR regulator, EppR-a recently characterized TetR-family transcriptional repressor-as also playing a role in biofilms. We show that an eppR-deficient strain is unable to form biofilms due to reduced expression of genes encoding adhesive pili. This occurs because EppR represses recA expression. Furthermore, we detected in biofilms an EppR-RecA complex that might lower intracellular RecA levels. Our findings provide further insight into both RecA regulation and the link between the DDR and biofilms.
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