Evidence map›Paper›PMID 41874376›Full record

ArticleAntimicrobial agents and chemotherapy2026

Benzoxaborole-modified azithromycins inhibit translation without inducing

Inna A Volynkina, Michael O Bortyazh, Chih-Wei Chen, Andrey G Tereshchenkov, Anastasiia O Karakchieva, Dmitrii A Lukianov, Ekaterina S Komarova, Alexey E Tupikin, Dmitry A Skvortsov, Anna N Tevyashova and 7 more

Abstract read
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In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Approaches for Studying Context Specificity of Translation Inhibitor Action.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Inna A Volynkina *Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0002-3852-653X
Michael O Bortyazh *Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0009-0000-0783-4321
Chih-Wei Chen *Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7493-3944
Andrey G TereshchenkovA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0002-3293-3951
Anastasiia O KarakchievaDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0009-0000-9424-0168
Dmitrii A LukianovDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0003-1413-9559
Ekaterina S KomarovaDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0002-6285-6395
Alexey E TupikinInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Novosibirsk Region, Russia.ORCID 0000-0002-8194-0322
Dmitry A SkvortsovDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0001-8336-8596
Anna N TevyashovaSchool of Science, Constructor University, Bremen, Germany.ORCID 0000-0003-1091-1011
Alexander S TikhomirovLaboratory of Synthesis of Antibiotics Overcoming Drug Resistance, Gause Institute of New Antibiotics, Moscow, Russia.ORCID 0000-0002-6418-1539
Vadim N TashlitskyDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0003-4100-2419
Marsel R KabilovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Novosibirsk Region, Russia.ORCID 0000-0003-2777-0833
Andrey E ShchekotikhinLaboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, Moscow, Russia.ORCID 0000-0002-6595-0811
Olga A DontsovaDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0003-3400-9882
Yury S PolikanovDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0002-5064-0327
Petr V SergievDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID 0000-0001-8866-1863

Funding

Illinois State Startup FundsMinistry of Science and Higher Education of the Russian Federation 075-00483-25-03NIGMS NIH HHS R01-GM132302Russian Science Foundation 21-64-00006-P
6 · The paper itself

Abstract

The rapid increase in antimicrobial resistance underscores the urgent need for new antibacterial agents. One promising strategy involves designing novel compounds through targeted chemical modifications of existing antibiotics. Azithromycin (AZI), a widely used macrolide, has served as a versatile scaffold for developing numerous antibacterial candidates. However, the mechanistic consequences of such modifications remain largely unexplored. Here, we characterize the activity and mechanism of action of three AZI-benzoxaborole (AZI-BB) conjugates. We show that these compounds inhibit bacterial translation

Indexed as

Anti-Bacterial AgentsAzithromycinEscherichia coliMethyltransferasesProtein BiosynthesisErythromycinGene Expression Regulation, BacterialMacrolidesMicrobial Sensitivity TestsRNA, Ribosomal, 23SAnti-Bacterial AgentsAzithromycinErythromycinMacrolidesMethyltransferasesRNA, Ribosomal, 23Santibiotic resistanceazithromycin derivativesbenzoxaborolescontext specificitymacrolidesmechanism of actiontranslation

Identifiers

PMID41874376
PMCPMC13148051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.