ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026
Modulation of alveolar macrophages by sex as a biological variable.
Article in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alveolar macrophages (AMs) play a key role in the innate immune system and the pathogenesis of bronchopulmonary dysplasia (BPD), a condition with a significant sex bias. However, the influence of biological sex on AM immunometabolism remains poorly defined. We tested the hypothesis that female AMs would exhibit greater metabolic resilience (less impact on their mitochondrial function) compared with male AMs upon exposure to hyperoxia. We characterized bioenergetic profiles of male (MH-S) and female (AMJ2-C11) adult murine AM cell lines and primary neonatal AMs from C57BL/6 pups. Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were quantified using Seahorse extracellular flux analysis at baseline and following 48 h of hyperoxia (85% O
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