Evidence map›Paper›PMID 41874225›Full record

ArticleMicrobiology spectrum2026

Strain-dependent disease progression and necrotizing granuloma formation in a murine model induced by virulent strains of

Haruka Hikichi, Shiho Omori, Hajime Nakamura, Shintaro Seto, Koji Furuuchi, Kozo Morimoto, Minako Hijikata, Naoto Keicho

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haruka Hikichi *Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Shiho Omori *Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Hajime Nakamura *Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Shintaro SetoDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.ORCID 0000-0001-8980-7377
Koji FuruuchiRespiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.ORCID 0000-0002-1208-7698
Kozo MorimotoRespiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Minako HijikataDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Naoto KeichoDepartment of Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.ORCID 0000-0001-8232-9448

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IMPORTANCE: The global incidence of pulmonary disease (PD) caused by non-tuberculous mycobacteria, particularly Mycobacterium avium complex (MAC), is increasing. However, the mechanisms underlying its pathological heterogeneity and variable treatment outcomes remain poorly understood. Here, we establish a murine model that recapitulates the key features of progressive MAC-PD, including necrotizing granuloma formation. We also demonstrate strain-specific differences in treatment responses despite comparable

Indexed as

drug susceptibilitygranulomamouse modelMycobacterium avium complexnecrotizing granuloma

Identifiers

PMID41874225
PMCPMC13142028

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.