ArticleParasite (Paris, France)2026
Host genetic background influences the severity of disease in Schistosoma haematobium infections.
Article in Parasite (Paris, France), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Host genetic factors influence the severity of infectious diseases, including schistosomiasis, which are major public-health burdens in Africa. While the role of host genetic background in Schistosoma mansoni infection has been clearly established, this link remains poorly explored for S. haematobium infections (Sh). Therefore, this study aims to investigate the relationship between genetic background and morbidity associated with urogenital schistosomiasis using a candidate gene approach. We analyzed urine samples from 334 Beninese men, measuring urinary eosinophil cationic protein (ECP) by ELISA as a marker for bladder inflammation. Abdominopelvic ultrasonography was performed in a subgroup of 146 participants (69 Sh-positive and 77 Sh-negative) to assess morbidities associated with Schistosoma infection. Blood samples were analyzed for TNF-α levels by ELISA and for TNF-α promoter polymorphisms by sequencing to assess associations between genetic variation and morbidity. Results showed that 25.4% of Sh+ had significantly higher mean TNF-α (U = 5888; p = 0.0098) and ECP (U = 912.5; p < 0.0001) levels than Sh-. Positive correlations were observed between egg count and both ECP (Tau = 0.4016; p < 0.0001) and TNF-α levels (Tau = 0.2238; p = 0.014). Morbidity mainly included bladder irregularities (6%), thickening (29%), and kidney dilation (6%). The G mutant allele on the rs3093660 marker was significantly associated with morbidity (χ
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.