Evidence map›Paper›PMID 41874168›Full record

ArticleMicrobiology spectrum2026

Paola Martinez-Murillo, Catia Alvarez, Francesco Santoro, Maria Novedrati, Chiara Sonnati, Giorgio Montesi, Simone Lucchesi, Donata Medaglini, Isabella Eckerle, Claire-Anne Siegrist and 1 more

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paola Martinez-Murillo *Center of Vaccinology, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-0888-3867
Catia Alvarez *Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-4247-2837
Francesco SantoroDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.ORCID 0000-0003-3052-3518
Maria NovedratiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Chiara SonnatiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Giorgio MontesiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Simone LucchesiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Donata MedagliniDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Isabella EckerleDepartment of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Claire-Anne SiegristCenter of Vaccinology, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
VEBCON, VSV-EBOVAC, and VSV-EBOPLUS Consortia

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recombinant vesicular stomatitis virus-vectored Zaire Ebola virus glycoprotein (rVSVΔG-ZEBOV-GP) vaccine, while effective and well-tolerated, exhibits notable reactogenicity, manifesting in expected adverse events (AEs), such as fever, headache, and pain, along with rare, unexpected AEs, including skin lesions, cutaneous vasculitis, and transient arthritis. The presence or absence of AEs following rVSVΔG-ZEBOV-GP vaccination is associated with a specific innate plasma signature. This study aims to elucidate IMPORTANCE: Our study expanded knowledge about the cellular tropism of rVSVΔG-ZEBOV-GP vaccine toward peripheral blood mononuclear cells and cell lines derived from tissues (skin, vessels, and joints) associated with unexpected AEs, as well as their possible contribution to the vaccine-induced innate response. Using

Indexed as

adverse eventsinnate responserVSVΔG-ZEBOV-GPvaccination

Identifiers

PMID41874168
PMCPMC13141887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.