Evidence map›Paper›PMID 41874056›Full record

ArticlePharmacy (Basel, Switzerland)2026

Real-World Comparison of Intravenous vs. Oral Antimicrobial Therapy for Bone and Joint Infections.

Maura Kreiser, Sarah Al Mansi, Ismaeel Yunusa, Caroline Derrick, P Brandon Bookstaver, Majdi N Al-Hasan, Yorika Hammett, Morgan Pizzuti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maura KreiserPrisma Health Richland, Columbia, SC 29203, USA.ORCID 0000-0001-6877-0907
Sarah Al MansiPrisma Health Tuomey, Sumter, SC 29150, USA.ORCID 0009-0004-7898-1379
Ismaeel YunusaDepartment of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0002-9107-8561
Caroline DerrickPrisma Health Richland, Columbia, SC 29203, USA.ORCID 0000-0002-4404-7965
P Brandon BookstaverPrisma Health Richland, Columbia, SC 29203, USA.ORCID 0000-0002-4409-0963
Majdi N Al-HasanPrisma Health Richland, Columbia, SC 29203, USA.
Yorika HammettPrisma Health Tuomey, Sumter, SC 29150, USA.
Morgan PizzutiPrisma Health Richland, Columbia, SC 29203, USA.ORCID 0000-0002-8282-4841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Well-designed randomized controlled trials (RCTs) have demonstrated safe and effective use of oral antimicrobial therapy for bone and joint infections. Application of data for implementation into real-world practice, however, has inherent challenges. This retrospective cohort study compared real-world use of intravenous versus oral antimicrobial therapy in bone and joint infections within a large healthcare system comprising both academic and community medical centers. The primary outcome was the proportion of treatment failure. Key secondary outcomes included the proportion of patients with logistical failure and risk factors associated with treatment and logistical failure. Among 166 patients included, 136 (82%) and 30 (18%) received predominantly intravenous and oral antimicrobial therapy, respectively. Treatment failure occurred in (77/121) 64% versus (18/25) 72% of patients in the intravenous and oral antimicrobial groups (

Indexed as

osteomyelitisseptic arthritisspinal infectionsStaphylococcus aureus

Identifiers

PMID41874056
PMCPMC13010755

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.