ArticleHuman vaccines & immunotherapeutics2026
Early diagnosis pathway for laboratory testing in the context of pertussis resurgence.
Article in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The resurgence of pertussis continues to be a global public health concern, especially in China in recent years. It is critical to identify atypical cases in adolescents and adults and to improve sensitivity to early laboratory diagnosis. The subjects were laboratory-confirmed cases in Chaoyang district between 2018 and 2023, detected through pertussis symptom surveillance, or reported in the National Notifiable Disease Reporting System. Logistic regression and decision tree models were used to examine potential factors influencing laboratory diagnostic sensitivity. Among the 446 laboratory-confirmed cases, the sensitivity of PCR and serological diagnosis of single serums was 83.4% and 49.5%. Logistic regression analysis showed that age and vaccination, disease course at sampling, and years of onset were the factors that affected the sensitivity of laboratory diagnosis (
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