Evidence map›Paper›PMID 41873888›Full record

ArticleJournal of immunology research2026

Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease.

Mari Nishida, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Aya Ushio, Takaaki Tsunematsu, Keiko Aota, Naozumi Ishimaru

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mari NishidaDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, tokushima-u.ac.jp.
Kunihiro OtsukaDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, tokushima-u.ac.jp.ORCID https://orcid.org/0000-0002-3546-8143
Ruka NagaoDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, tokushima-u.ac.jp.
Shigefumi MatsuzawaDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, tokushima-u.ac.jp.
Aya UshioDepartment of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan, tmd.ac.jp.
Takaaki TsunematsuDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, tokushima-u.ac.jp.
Keiko AotaDepartment of Oral and Maxillofacial Disease Control, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, tokushima-u.ac.jp.
Naozumi IshimaruDepartment of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan, tmd.ac.jp.ORCID https://orcid.org/0000-0003-1087-8338

Funding

Japan Society for the Promotion of Science 22K10172Japan Society for the Promotion of Science 23H00438Japan Society for the Promotion of Science 23K15976Japan Society for the Promotion of Science 25K22683
6 · The paper itself

Abstract

Sjögren disease (SjD) is an autoimmune disorder that predominantly affects the exocrine glands, and advancing age is recognized as an important risk factor for its development. However, the mechanisms linking age and disease progression remain poorly understood. Age-associated B cells (ABCs), a subset of B cells that increase with age, have been implicated in autoimmune responses, but their role in SjD pathogenesis has not been fully clarified. In this study, we examined labial salivary glands (LSGs) from 44 SjD patients and 11 non-SjD sicca controls. T-bet

Indexed as

AgingB-LymphocytesInterferon-gammaInterleukinsSalivary GlandsSjogren's SyndromeAdultAgedAge FactorsAnimalsDisease Models, AnimalFemaleHumansInterleukin-21MaleMiceInterferon-gammaInterleukin-21Interleukinsage-associated B cell (ABC)autoimmune diseaseSjögren disease (SjD)

Identifiers

PMID41873888
PMCPMC13140891

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.