ArticleGenome biology and evolution2026
The Missing Piece: Functional Telomerase Restored in the Beetle Model.
Article in Genome biology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Species-rich and genomically diverse: comparative genomics reveals how fusions, fissions, and sex chromosomes have shaped beetle evolution.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
The red flour beetle Tribolium castaneum yielded the first resolved telomerase reverse transcriptase structure but lacked a known telomerase RNA. We identify two telomerase RNA paralogs in Tribolium, confirm their expression, and reconstitute active telomerase in vitro. Extending this approach across Coleoptera, we detect telomerase RNA homologs in diverse beetle lineages, with conserved cores but lineage-specific template and telomeric DNA variants. Our findings establish Tribolium as a powerful model for telomerase biochemistry, illuminate the evolutionary plasticity of beetle telomere maintenance, and reveal a consistent lack of telomerase in several derived Scarabaeoidea subfamilies, pinpointing its evolutionary loss within this beetle clade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.