Evidence map›Paper›PMID 41873558›Full record

Observational studyNeurogastroenterology and motility2026

Relationship Between Heart Rate Variability and Sleep Among Girls and Boys With Abdominal Pain-Related Disorders of Gut-Brain Interaction.

Kendra J Kamp, Robert L Burr, Camden E Matherne, Emily Simonds, Tasha Murphy, Margaret M Heitkemper, Rona L Levy, Robert J Shulman, Miranda A L van Tilburg

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kendra J KampDepartment of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-7753-3564
Robert L BurrDepartment of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, Washington, USA.
Camden E MatherneDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Emily SimondsDepartment of Anesthesia and Critical Care Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Tasha MurphySchool of Social Work, University of Washington, Seattle, Washington, USA.
Margaret M HeitkemperDepartment of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, Washington, USA.
Rona L LevySchool of Social Work, University of Washington, Seattle, Washington, USA.
Robert J ShulmanBaylor College of Medicine, Houston, Texas, USA.
Miranda A L van TilburgSchool of Social Work, University of Washington, Seattle, Washington, USA.

Funding

DO BIOMARKERS PREDICT RESPONSE TO A PEDIATRIC CHRONIC PAIN SYMPTOM MANAGEMENT PROGRAM?R01NR016786 · NINR · BAYLOR COLLEGE OF MEDICINE · PI LEVY, RONA L., SHULMAN, ROBERT J · 2018 to 2023
$2.9M
A Comprehensive Self-Management Intervention for individuals with Inflammatory Bowel DiseaseK23NR020044 · NINR · UNIVERSITY OF WASHINGTON · PI KAMP, KENDRA JOY · 2022 to 2024
$430k
NINR NIH HHS K23 NR020044NINR NIH HHS R01 NR016786
6 · The paper itself

Abstract

backgroundChildren with abdominal pain-related disorders of gut-brain interaction (AP-DGBI) often experience sleep disturbances which may be linked to the autonomic nervous system. Heart rate variability (HRV) is a non-invasive measure of autonomic nervous system activity. Our aim was to examine if HRV was associated with characteristics of disturbed sleep in children with AP-DGBI in order to elucidate the underlying physiological mechanisms of disturbed sleep.

methodsThis analysis used baseline data from a randomized control trial of 156 children ages 7-12 years with AP-DGBI. HRV was measured after dinner using a Polar monitor. Sleep disturbances were evaluated using the Children's Sleep Habits Questionnaire. Associations between HRV indices and sleep characteristics were determined using partial correlations controlling for age and stratified by sex. KEY

resultsAmong girls, higher parasympathetic activity (Ln RMSSD and Ln pNN50) was associated with longer sleep onset delay while lower heart rate was correlated with increased sleep anxiety. Among boys, lower autonomic balance (Ln LF/HF ratio) was associated with increased daytime sleepiness. In both sexes, lower low frequency HRV was associated with greater sleep-disordered breathing. Post hoc analysis of multiple indices revealed that children with sleep-disordered breathing had significantly lower HRV vs. those without disordered breathing. CONCLUSIONS & INFERENCES: The autonomic nervous system may be a potential mechanism which impacts sleep among children with AP-DGBI. Future longitudinal studies are needed to confirm this relationship.

Indexed as

Abdominal PainAutonomic Nervous SystemBrainBrain-Gut AxisHeart RateSleepSleep Wake DisordersChildFemaleHumansMaleRandomized Controlled Trials as Topicabdominal pain‐related disorders of gut‐brain interactionautonomic nervous systemchildrenheart rate variabilitysleep‐disordered breathingsleep disturbances

Identifiers

PMID41873558
PMCPMC13010199

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.