Evidence map›Paper›PMID 41873487›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

ESCRT-Mimetic Nanodegrader Targets STING for Anti-Inflammatory Therapy.

Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fuyuan ZhouChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Technology Innovation Center of Smart Dental Medical Devices, Innovation and Transformation of Dental Medical Devices Engineering Research Center of Chongqing Education Commission of China, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Qiming ZhaiChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Technology Innovation Center of Smart Dental Medical Devices, Innovation and Transformation of Dental Medical Devices Engineering Research Center of Chongqing Education Commission of China, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Zhihao YaoChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Technology Innovation Center of Smart Dental Medical Devices, Innovation and Transformation of Dental Medical Devices Engineering Research Center of Chongqing Education Commission of China, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Qing LiChongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Yan YangChongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Si WangChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Technology Innovation Center of Smart Dental Medical Devices, Innovation and Transformation of Dental Medical Devices Engineering Research Center of Chongqing Education Commission of China, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Chao HuangChongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Liangjing XinChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Technology Innovation Center of Smart Dental Medical Devices, Innovation and Transformation of Dental Medical Devices Engineering Research Center of Chongqing Education Commission of China, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Tao ChenChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Technology Innovation Center of Smart Dental Medical Devices, Innovation and Transformation of Dental Medical Devices Engineering Research Center of Chongqing Education Commission of China, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-5658-5525
Jinlin SongChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Technology Innovation Center of Smart Dental Medical Devices, Innovation and Transformation of Dental Medical Devices Engineering Research Center of Chongqing Education Commission of China, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.

Funding

Chongqing Science and Technology Bureau CSTB2024NSCQ-LZX0055Graduate Scientific Research Innovation Project of Stomatology, Chongqing Medical University KQY202414Medical youth top talent program of Chongqing YXQN202454National Key R&D of Program of China 2022YFC2504200National Natural Science Foundation of China 82201075National Natural Science Foundation of China 82401115National Natural Science Foundation of China U22A20314National Science Fund for Excellent Young Scholars 32322044Postdoctoral Innovation Talents Support program of Chongqing CQBX202313
6 · The paper itself

Abstract

Excessive STING activation underlies the pathogenesis of diverse inflammatory diseases, yet conventional inhibitors often fail to restore its physiological degradation. To address this, we designed a biomimetic STING-directed autophagy-targeting chimera (STING-ATTEC) that recapitulates the endogenous ESCRT-mediated degradation pathway, with computational modeling providing preliminary guidance for molecular optimization. The optimized STING-ATTEC was encapsulated within folate-modified cationic lipid nanoparticles (FA-LNP

Indexed as

Anti-Inflammatory AgentsEndosomal Sorting Complexes Required for TransportInflammationMembrane ProteinsNanoparticlesAnimalsAutophagyHumansMiceSTING ProteinAnti-Inflammatory AgentsEndosomal Sorting Complexes Required for TransportMembrane ProteinsSTING Proteinautophagy‐tethering chimerainflammationlipid nanoparticlemacrophage targetingtargeted protein degradation

Identifiers

PMID41873487
PMCPMC13317561

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.