ArticleJournal of inflammation research2026
The Diagnostic and Prognostic Value of Procalcitonin and High-Sensitivity C-Reactive Protein in Early-Stage Burn Sepsis: A Retrospective Cohort Study.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) for early diagnosis and prognosis of burn sepsis. Methods: A retrospective cohort study included 159 critically ill burn patients (2021-2024) divided into burn sepsis group (n=72) and non-sepsis group (n=87). Clinical data were analyzed to evaluate the biomarkers' diagnostic value. Sepsis patients were further grouped by outcome (mortality/survival) to explore biomarkers' relationship with severity and prognosis. Results: Compared with the non-sepsis group, the sepsis group had significantly higher early PCT and hs-CRP (P < 0.05), with no significant differences in IL-6, white blood cell (WBC) count, or body temperature. Multivariate logistic regression identified PCT and hs-CRP as independent diagnostic factors. Their areas under the receiver operating characteristic (ROC) curve were 0.802 and 0.768, respectively; combined areas under the curve (AUC) was 0.821, all higher than those of body temperature, WBC, and IL-6 (0.536, 0.536, 0.579; P < 0.05). In sepsis patients, PCT was positively correlated with creatinine (r=0.625, R Conclusion: PCT and hs-CRP are useful for early burn sepsis diagnosis, with combined detection improving efficacy. Body temperature, WBC, and IL-6 have limited diagnostic value. Elevated PCT may relate to acute kidney injury. Early biomarker levels correlate with sepsis severity but have limited prognostic value.
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