ArticleCureus2026
Premature Coronary Artery Disease and Familial Dyslipidemia in Patients Presenting With Acute Coronary Syndrome: A Tertiary Cardiac Center Registry.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Clinical and Genetic Factors Associated with Multivessel Coronary Artery Disease: A Cross-Sectional Study of CYP2C19 Polymorphisms and Metabolic Comorbidities.International journal of general medicine · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPremature coronary artery disease (CAD) in patients presenting with acute coronary syndrome (ACS) is an increasing clinical concern driven by genetic predisposition and lifestyle factors. This study compared clinical and laboratory characteristics of premature versus non-premature CAD and identified predictors of early-onset disease.
methodsThis was a cross-sectional observational study of 2,000 patients admitted with confirmed ACS. Premature CAD was defined as males <55 years and females <65 years. Clinical, laboratory, and cardiological variables were compared between groups.
resultsFrom December 2021 to March 2025, 2,000 patients were enrolled. Premature CAD occurred in 637 patients (31.9%), who were younger (median age 49 years) and predominantly male (68.4%). Smoking (32.8% vs. 9.4%), family history of dyslipidemia (20.4% vs. 3.7%), higher total cholesterol (174.0 vs. 145.0 mg/dL, p<.001), higher low-density lipoprotein (LDL) cholesterol (108.3 vs. 85.1 mg/dL, p<.001), and higher corrected LDL (155.8 vs. 147.3 mg/dL, p<.001) were more common in premature CAD, whereas diabetes and hypertension were less frequent. Independent predictors included smoking (OR 4.71, 95% CI 3.68 6.03), family history of dyslipidemia (OR 6.73, 95% CI 4.78 9.48), cholesterol ≥200 mg/dL (OR 2.26, 95% CI 1.80 2.83), LDL ≥100 mg/dL (OR 2.10, 95% CI 1.74 2.54), and hypertriglyceridemia (OR 1.77, 95% CI 1.45 2.17).
conclusionsPremature CAD in patients presenting with ACS demonstrates a risk profile dominated by smoking and familial dyslipidemia rather than metabolic comorbidities. Early lipid screening and aggressive modification of lifestyle risk factors are essential to reduce early atherosclerotic disease burden.
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