Evidence map›Paper›PMID 41873279›Full record

ArticleCureus2026

Acute Necrotizing Encephalopathy of Childhood: A Report of Two Cases.

Amal Akammar, Salma Abouchiba, Hajar Ouazzani, Ismail Chaouche, Nizar El Bouardi, Meriem Haloua, Badreddine Alami, Moulay Youssef Alaoui Lamrani, Mustapha Maaroufi, Meryem Boubbou

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amal AkammarDepartment of Mother and Child Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Salma AbouchibaDepartment of Mother and Child Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Hajar OuazzaniDepartment of Mother and Child Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Ismail ChaoucheDepartment of Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Nizar El BouardiDepartment of Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Meriem HalouaDepartment of Mother and Child Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Badreddine AlamiDepartment of Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Moulay Youssef Alaoui LamraniDepartment of Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Mustapha MaaroufiDepartment of Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.
Meryem BoubbouDepartment of Mother and Child Radiology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, MAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute necrotizing encephalopathy of childhood (ANEC) is a rare, severe disorder in previously healthy infants and children, associated with high morbidity and mortality. Early recognition is essential for timely management. We report two pediatric cases. A three-month-old female infant presented with hypotonia, feeding refusal, and lethargy; MRI revealed bilateral, symmetrical thalamic lesions with edema. A four-year-old female developed status epilepticus following a febrile illness; imaging showed diffuse, asymmetrical cortical and subcortical lesions, including hemorrhagic changes in the thalami and brainstem. Both patients received aggressive supportive care, immunomodulation with corticosteroids, and empiric antimicrobial therapy. The second patient also required intensive management for status epilepticus. ANEC presents with nonspecific symptoms such as fever, seizures, and altered consciousness. MRI is crucial for diagnosis, demonstrating characteristic lesions that may vary in distribution and severity. Early neuroimaging, prompt supportive care, and awareness of lesion variability are essential for accurate diagnosis and optimizing outcomes in children with ANEC.

Indexed as

acute necrotizing encephalitisbilateral thalamic lesionscentral nervous system infectionmagnetic resonance imagingrare neurological disorder

Identifiers

PMID41873279
PMCPMC13005995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.