Evidence map›Paper›PMID 41873056›Full record

ArticleCNS spectrums2026

Psychiatric comorbidity patterns across disability-based fibromyalgia phenotypes.

Kevin V Hackshaw, Michelle M Osuna-Diaz, Katherine R Sebastian, Shreya Madhav Nuguri, Silvia deLamo Castellvi, Lianbo Yu, M Monica Giusti, Zhanna Mikulik, Luis Rodriguez-Saona

Abstract read
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In one paragraph

Article in CNS spectrums, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kevin V HackshawMedicine, The University of Texas at Austin Dell Medical School, USA.ORCID 0000-0002-9780-7171
Michelle M Osuna-DiazMedicine, The University of Texas at Austin Dell Medical School, USA.
Katherine R SebastianMedicine, The University of Texas at Austin Dell Medical School, USA.
Shreya Madhav NuguriMedicine, The University of Texas at Austin Dell Medical School, USA.
Silvia deLamo CastellviFood Sciences and Technology, The Ohio State University, USA.
Lianbo YuBioinformatics, The Ohio State University Wexner Medical Center, USA.
M Monica GiustiFood Sciences and Technology, The Ohio State University, USA.
Zhanna MikulikMedicine, The Ohio State University Wexner Medical Center, USA.
Luis Rodriguez-SaonaFood Sciences and Technology, The Ohio State University, USA.

Funding

NIH HHS GR122808 (LRS),R61/33 NS117211 (KVH)
6 · The paper itself

Abstract

objectiveFibromyalgia (FM) is a heterogeneous chronic pain condition frequently accompanied by psychiatric symptoms. Although affective symptoms are highly prevalent, they are often treated as secondary correlates of pain or disability. This study examined whether psychiatric symptom profiles parallel disability severity or represent partially independent dimensions across disability-based FM phenotypes.

methodsWe analyzed a harmonized multisite cohort of adults with FM recruited from two academic medical centers. Disability-based phenotypes were defined using a validated percentile-based classification dichotomizing participants into low-impact and high-impact FM. Psychiatric domains were derived from standardized measures of depressive and anxiety-related symptoms. Multivariate clustering was used to identify affective profiles, and their distribution across disability phenotypes was examined. Dimensional analyses assessed the relationship between affective burden and functional impairment.

resultsAmong participants with complete psychiatric data (

conclusionsPsychiatric comorbidity in FM does not simply reflect pain severity or functional impairment. Instead, affective symptoms form partially independent dimensions that cut across disability-based phenotypes. These findings support a multidimensional neuropsychiatric framework for FM with implications for stratified assessment and personalized intervention.

Indexed as

FibromyalgiaMental DisordersPersons with DisabilitiesAdultComorbidityDisability EvaluationFemaleHumansMaleMiddle AgedPhenotypeSeverity of Illness Indexaffective symptomsdimensional psychopathologydisabilityFibromyalgiapsychiatric comorbidity

Identifiers

PMID41873056
PMCPMC13076076

What OpenQuestion holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.