ArticleImmunity, inflammation and disease2026
Diagnostic Value of Neutrophil CD64 in Differentiating Scrub Typhus From Febrile Diseases.
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Diagnostic Value of Neutrophil CD64 in Differentiating Scrub Typhus From Febrile Diseases.Immunity, inflammation and disease · 2026Article
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11 authors.
Funding
Abstract
backgroundScrub typhus, lacks specific early symptoms, and traditional serological tests have low sensitivity. This study shows that CD64 has superior diagnostic performance compared to CRP and PCT in bacterial infections.
methodsThis retrospective study analyzed 242 febrile patients admitted to the Jiangsu Province (Suqian) Hospital (January 2023-December 2024), categorized into non-specific fever (n = 186) and scrub typhus (n = 56). The CD64 expression was quantified via flow cytometry (BD FACS Canto II) within 48 h of admission. ROC analysis evaluated diagnostic performance using AUC, sensitivity, specificity, and Youden index. Mann-Whitney U and Chi-square tests compared groups (SPSS v26.0), with significance at p < 0.05.
resultsThe scrub typhus group had significantly higher CD64 levels (median: 2.90 [IQR: 1.00-5.20]) than non-specific fever (0.23 [0.10-0.58], p < 0.001). ROC analysis demonstrated CD64's high discriminatory power: AUC = 0.938 (95% CI: 0.882-0.995) for scrub typhus vs. non-specific fever (sensitivity = 91.7%, specificity = 89.8%). Traditional markers like WBC and lymphocyte percentage showed high discrimination against non-specific fever (AUC = 0.973-0.989).
conclusionThis study shows that CD64 is an efficient biomarker for differentiating scrub typhus from febrile diseases, offering crucial evidence for establishing rapid diagnostic pathways and holding value for early triage of febrile patients.
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