SynthesisPsycho-oncology2026
Efficacy of Mindfulness-Based Interventions for Reducing Cancer-Related Fatigue: A Systematic Review and Meta-Analysis.
Synthesis in Psycho-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
backgroundCancer-related fatigue (CRF) is a common and distressing symptom among patients with cancer. Although mindfulness-based interventions (MBIs) are increasingly applied for CRF management, evidence regarding their efficacy remains inconsistent.
aimsThis systematic review and meta-analysis aimed to evaluate the efficacy of MBIs in reducing CRF.
methodsPubMed, EMBASE, Web of Science, Cochrane, and CINAHL were comprehensively searched from database inception to August 31, 2025, for randomized controlled trials (RCTs) involving patients with cancer who received MBIs. The primary outcome of interest was fatigue. The risk of bias was assessed using the Cochrane risk-of-bias 2.0 tool. A meta-analysis was performed using a random-effects model, and standardized mean differences (SMDs) with 95% confidence intervals (CI) were calculated. Subgroup analyses, meta-regressions, publication bias assessments, and sensitivity analyses were also performed.
resultsA total of 29 RCTs involving 3178 participants were included. Compared with control interventions, MBIs were associated with significantly lower fatigue levels (SMD = -0.89; 95% CI: -1.23 to -0.55, p < 0.001). However, substantial heterogeneity was observed (I
conclusionsThis study demonstrates that MBIs are an efficacious approach for significantly reducing fatigue among patients with cancer, supporting the role and broader application of nonpharmacological strategies in managing CRF. However, substantial between-study heterogeneity, moderate certainty of evidence, and indications of publication bias warrant cautious interpretation of the pooled estimates.
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