ArticleDiabetes, obesity & metabolism2026
In Vivo Imaging of the Innate Immune System in the Pancreas in New-Onset and Long-Standing Type 1 Diabetes.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
objectiveType 1 diabetes (T1D) is an autoimmune disease, but knowledge of immune cell infiltration in the human pancreas is limited due to the risks associated with pancreatic biopsies. This study aimed to evaluate the feasibility of imaging innate immune cells in vivo using positron emission tomography (PET).
methodsWe used PET tracers targeting M1 macrophages ([
resultsBoth tracers enabled visualisation and quantification of pancreatic uptake. Uptake of both [ DISCUSSION: PET imaging of innate immune cells in the pancreas is feasible. While no increased macrophage or neutrophil activity was observed in new-onset T1D, increased tracer uptake in long-standing T1D may reflect late-stage inflammatory processes and fibrosis.
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