ArticleBiology direct2026
PHGDH mediated serine biosynthesis metabolism suppresses vascular calcification.
Article in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
backgroundVascular calcification is a major pathological process driving cardiovascular morbidity and mortality, yet effective therapies are lacking. This study aims to identify novel causal plasma proteins and therapeutic targets for vascular calcification through an integrative multi-omics approach and to further explore their functional roles and regulatory mechanisms in vascular calcification.
methodsWe performed a high-throughput Mendelian randomization (MR) analysis using protein quantitative trait loci from two large-scale proteomic studies (deCODE and UKB-PPP) as genetic instruments. Summary-level data for vascular calcification were obtained from genome-wide association studies. Candidate proteins underwent rigorous sensitivity analyses, colocalization, and external replication. Transcriptomic data were analyzed to assess expression changes in calcified vascular smooth muscle cells. Functional validation and mechanism exploration was conducted in high-phosphate-induced human aortic smooth muscle cells (HASMCs) and a 5/6 nephrectomy mouse model of vascular calcification using siRNA, overexpression plasmids, and the pharmacological inhibitor NCT-503. CLINICAL TRIAL NUMBER: Not applicable.
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