ReviewJournal of biological engineering2026
Engineered Metal-Organic Frameworks (MOFs)-electrospun nanofibers for wound healing: a review.
Review in Journal of biological engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Structure-Function Engineering of Hydrogel-MOF Polymer Composites for Regenerative Wound Dressings with Emerging Antiviral Biointerface Functions.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal-Organic Framework (MOF)/nanofiber composites represent a significant evolution in advanced wound care, offering a multi-functional platform for controlled therapeutic delivery and accelerated tissue regeneration. The superior performance of these systems is frequently reported with nearly 100% wound closure within 14 days and a broad-spectrum antimicrobial efficacy, yet the clinical translation remains contingent upon addressing technical and toxicological constraints. On the top of those constraints are the lack of long term stability data and precise dosing protocols in complex wound environments. This review provides a critical evaluation of these composites, analyzing established nanofibers impeded with zinc, copper, silver, zirconium alongside emerging iron -based MOFs that provide superior biocompatibility and enzymatic ‘chemodynamic’ activity, and cobalt systems which offer unique hypoxia-mimicking properties for angiogenesis. In this review the stability-toxicity paradox inherent in ion-releasing MOFs/nanofiber composites is emphasized. We further examine the structural hurdles of fabrication, specifically the rheological disruptions and interfacial mismatches that occur during electrospinning. Furthermore, the role of Machine Learning is evaluated as a predictive framework whose clinical accuracy is currently limited by the stochastic nature of the biological systems. Additionally, the impact of MOF architectures on nanofiber piezoelectricity is demonstrated, raising questions regarding the sustainability of electroactive effects during framework decomposition. In this way, this review identifies persistent research gaps in material stability and long-term biocompatibility, providing a realistic roadmap for the development of next-generation bioactive wound interfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.