ArticleJournal of ovarian research2026
Clinical correlation of apoptosis in human luteinized granulosa cells.
Article in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundApoptosis is a continuous process throughout follicular development and plays a critical role in normal ovarian physiology. Although the key apoptotic molecule-encoding genes have been well characterized, their associations with ovarian reserve and pregnancy outcomes remain controversial. Such inconsistency largely arises from confounding effects of uncontrolled variables and methodological limitations in the quantification of apoptosis. To address this knowledge gap, the present study systematically evaluated the correlation between granulosa cell apoptosis and ovarian reserve, as well as its subsequent impact on ovarian stimulation outcomes, using specific apoptotic marker gene expression analysis.
methodsA prospective cohort study was conducted involving 75 patients undergoing assisted reproductive technology(ART). Luteinized granulosa cells were isolated from collected follicular fluid samples, and total RNA was extracted following standard protocols. Quantitative real-time polymerase chain reaction (qPCR) was then utilized to quantify the relative transcript levels of caspase-3, caspase-8, Bax, P53, PTEN, and Bcl-2 genes.
resultsCompared with patients with normal ovarian reserve (NOR), those with diminished ovarian reserve (DOR) exhibited significantly fewer antral follicles, retrieved oocytes, fertilized oocytes, high-quality embryos, blastocysts, and high-quality blastocysts, along with a markedly lower clinical pregnancy rate. Furthermore, the relative transcript level of caspase-3 was significantly upregulated in DOR patients and was notably higher in the non-pregnant subgroup.
conclusionNotably, significantly higher transcript-level expression of caspase-3 in mural granulosa cells was correlated with DOR. Collectively, these findings suggest that the caspase-3 gene may play a role in regulating clinical pregnancy outcomes, thereby highlighting its potential as a molecular marker associated with ovarian reserve and pregnancy success.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.