Trial reportBJOG : an international journal of obstetrics and gynaecology2026
Prenatal 17-Alpha-Hydroxyprogesterone Caproate Exposure in Twins and Childhood Outcomes: 14-Year Follow-Up of a Randomised Trial.
Trial report in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveLong-term child outcomes after intra-uterine exposure to 17-alpha-hydroxyprogesterone caproate (17-OHPC) versus placebo.
designFollow-up of the AMPHIA randomised controlled trial assessing neonatal outcomes after weekly 17-OHPC injections compared to placebo in multiple pregnancies.
settingMulticentre. POPULATION OR SAMPLE: Children born in the AMPHIA study.
methodsChildren were assessed at 11-14 years of age by record linkage and through self-reported, parental and teacher questionnaires. Mean differences or odds ratios (OR) with 95% confidence intervals (95% CI) were calculated with cluster robust standard errors for twins and adjustment for confounders using inverse probability weighting (IPW).
main outcome measuresChild mortality, educational attainment, cognition, behaviour, gender identity, general health, and a composite of abnormal development.
resultsUp to 14 years, 60/1356 children had died (n = 24 17-OHPC and n = 36 placebo (OR 0.75 95% CI 0.36-1.53)). Record linkage was completed for 1027/1296 (79%) surviving children (n = 517 17-OHPC and n = 510 placebo). No significant difference was found regarding educational attainment. Detailed developmental outcomes through questionnaires were collected for 303/1296 (23%) surviving children (n = 159 17-OHPC and n = 144 placebo). No differences in cognition, behaviour, gender identity, and general health up to 14 years of age were found between both groups. The composite of abnormal development did not differ between 17-OHPC (23.3%) and placebo (20.1%) groups (OR 1.31 95% CI 0.66-2.56).
conclusionIn offspring of women with a multiple pregnancy, the use of 17-OHPC in pregnancy is unlikely to provide positive or negative effects on child outcome related to mortality, educational attainment, cognition and behaviour.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.