Evidence map›Paper›PMID 41872676›Full record

ArticleOncoimmunology2026

Sex determines the natural killer cell-mediated immunity against pancreatic cancer.

Elise Arlt, Nadine Bley, Alexander Rausch, Sandra Hauser, Jens Pietzsch, Danny Misiak, Thomas Liehr, Stefanie Kankel, Theresa Dautz, Luisa Dreher and 3 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elise ArltInstitute of Anatomy and Cell Biology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0009-0007-4887-032X
Nadine BleySection Molecular Cell Biology, Institute for Molecular Medicine, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0002-4531-7998
Alexander RauschSection Molecular Cell Biology, Institute for Molecular Medicine, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Sandra HauserDepartment of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Jens PietzschDepartment of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.ORCID 0000-0002-1610-1493
Danny MisiakSection Molecular Cell Biology, Institute for Molecular Medicine, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0001-5931-8425
Thomas LiehrJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany.
Stefanie KankelJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany.
Theresa DautzInstitute of Anatomy and Cell Biology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Luisa DreherInstitute of Anatomy and Cell Biology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Xiángméng KǒngInstitute of Anatomy and Cell Biology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Heike KielsteinInstitute of Anatomy and Cell Biology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Ivonne Bazwinsky-WutschkeInstitute of Anatomy and Cell Biology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0002-2650-136X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) ranks among the most aggressive malignancies and exhibits a higher prevalence and poorer prognosis in male patients. While both the importance of natural killer (NK) cells in anti-tumor immunity and sex differences in NK cell function are well established, the interplay between biological sex and NK cell-mediated responses in PDAC has not been systematically addressed. Here, we provide novel insights revealing that both the intrinsic cytotoxic capacity of NK cells and the tumor microenvironment differ between sexes and jointly modulate anti-tumor immunity in PDAC. Using

Indexed as

Carcinoma, Pancreatic DuctalKiller Cells, NaturalPancreatic NeoplasmsAnimalsCell Line, TumorCytotoxicity, ImmunologicFemaleHumansImmunity, CellularMaleMiceMice, Inbred C57BLSex FactorsTumor Microenvironmentcell linesgender differencesimmune evasionImmune responseimmunotherapyinnate immune systemkilling assaymouse modelsmultiplex imagingtumor microenvironment

Identifiers

PMID41872676
PMCPMC13014558

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.