ArticleInternational endodontic journal2026
Decellularized Dental Pulp Matrix Hydrogel Promotes Functional Endodontic Regeneration In Situ.
Article in International endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Extracellular Matrix-Based and Extracellular Matrix-Bioinspired Scaffolds for Extracellular Vesicle Delivery in Dental Pulp Regeneration: A Narrative Review.Biotech (Basel (Switzerland)) · 2026Review
- Decellularized dental pulp extracellular matrix for pulp-dentin regeneration: a narrative review of processing, bioactivity, delivery, preclinical evidence, and translational challenges.Frontiers in dental medicine · 2026Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
aimAn appropriate scaffold material is crucial for the success of tissue-engineered regenerative endodontic therapies. In this study, a porcine-derived decellularized dental pulp matrix hydrogel (pDDPM-G) was prepared and employed as the primary scaffold for in situ regeneration of the pulp-dentine complex in beagle dogs.
methodsIn the orthotopic pulp regeneration model, pDDPM-G was either directly injected into the root canals of canine teeth (with or without blood induction) or used as a carrier for transplantation of dental pulp stem cells (DPSCs). Collagen type I (COL I) injection (with or without blood induction) and revascularization therapy (blood induction alone) served as controls. Computed tomography images were acquired before and after surgery. Histological and immunofluorescence analyses were conducted for in vivo characterization at 14 and 90 days post-surgery, respectively.
resultsThe experimental results showed that the application of pDDPM-G was critical to all three regenerative endodontic procedures, whether combined with DPSC transplantation, used with blood induction (BI), or applied alone for cell homing. Integration of pDDPM-G reduced the extent of intracanal calcification compared with conventional revascularization therapy (BI) alone. Furthermore, expression of all representative proteins, including odontoblast-like (DSPP and DMP1), angiogenic (CD31 and KDR) and neurogenic (MAP2 and TUJ1) markers, was much higher in all pDDPM-G-containing groups than in the BI+COL I, COL I and BI groups.
conclusionThis study demonstrated the significance of pDDPM-G in functional endodontic regeneration using an orthotopic canine model. It was found that the use of pDDPM-G was not only beneficial for root development but also facilitated pulp-like tissue morphogenesis, dentinogenesis, angiogenesis and neurogenesis, thereby reconstructing hierarchically distributed functional pulp-dentine complexes.
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