ArticleJournal of molecular histology2026
Histomorphological analysis of the relationship between Helicobacter pylori infection of the gastric mucosa and host immunity strength.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The objective of this study was to investigate the histomorphological characteristics of H. pylori colonization in the gastric mucosa in relation to the strength of the host’s immune response. A total of 2,443 endoscopic biopsy specimens were collected from individuals infected with gastric H. pylori. A detailed histological examination and an immunohistochemical detection were conducted on these samples. Among these, 54 patients with high-grade intraepithelial neoplasia underwent endoscopic submucosal dissection; 21 with H. pylori-infected gastric cancer and 5 with fibromatosis-like undifferentiated carcinoma underwent surgical resection. H. pylori infection in the gastric mucosa progressed to the development of gastric cancer in the following six stages, also referred to as six phases: the mucous layer infection phase, the surface epithelial cell infection phase, the neck mucous cell compensatory phase, the lamina propria lesion phase, the proliferative zone stem cell phase, and the intraepithelial neoplasia phase. The histopathological characteristics of H. pylori infection-induced epithelial cell damage and immune cell involvement at different stages were identified in this study based on the degree and depth of gastric mucosal injury caused by H. pylori infection. Additionally, based on the host’s immune status, distinct histomorphological features and immunophenotypes corresponding to strong and weak immune responses were distinguished. Histomorphological analysis of gastric mucosa infected with H. pylori in combination with assessment of the body’s immune response can facilitate clinicians in implementing immune interventions tailored to different stages of the infection, thereby achieving precise and targeted treatment.
Indexed as
Identifiers
41872592What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.