Preparation of an activatable benzothiadiazole-based nanoprobe for multispectral optoacoustic and NIR-II fluorescence dual-mode imaging of liver injury.

Yinglong Wu, Chaobang Zhang, Junjie Chen, Fang Zeng, Shuizhu Wu, Yanli Zhao

Abstract readReview

In one paragraph

Review in Nature protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yinglong Wu *School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.

Chaobang Zhang *Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou, China.ORCID http://orcid.org/0000-0002-8729-6865

Junjie ChenBiomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou, China.

Fang ZengBiomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou, China.

Shuizhu WuBiomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou, China. shzhwu@scut.edu.cn.ORCID http://orcid.org/0000-0002-6739-0694

Yanli ZhaoSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore. zhaoyanli@ntu.edu.sg.ORCID http://orcid.org/0000-0002-9231-8360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light-excited dual-mode imaging that integrates multispectral optoacoustic tomography (MSOT) and near-infrared region II fluorescence (NIR-II FL) imaging allows complementary deep-tissue visualization with high anatomical resolution and molecular sensitivity, thereby enhancing the accuracy of biomedical diagnostics. Activatable probes further advance this approach by producing signals upon recognition of disease-related biomarkers, which reduces background interference and improves imaging specificity. BTPE-NO

Indexed as

Chemical and Drug Induced Liver InjuryFluorescent DyesLiverNanoparticlesOptical ImagingPhotoacoustic TechniquesThiadiazolesAnimalsFluorescent Chemosensor CompoundsHydrogen PeroxideMiceSpectroscopy, Near-Infraredbenzo-1,2,3-thiadiazoleFluorescent Chemosensor CompoundsFluorescent DyesHydrogen PeroxideThiadiazoles

Identifiers

PMID41872529

DOI10.1038/s41596-026-01338-w

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.