Evidence map›Paper›PMID 41872517›Full record

ArticleMolecular psychiatry2026

BDNF restores impaired long-term potentiation of GABAergic synapses induced by chronic ethanol exposure in the VTA and attenuates reward-seeking behavior.

Jun-Wei Xiong, Meng-Yao Dou, Ying Wang, Ting Zeng, Xunzhong Qi, Jia-Ning Wei, Xiao-Wei Shi, Dan-Dan Cui, Hui-Zhen Dai, Chen-Yu Du and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jun-Wei XiongDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.ORCID http://orcid.org/0009-0001-5973-5613
Meng-Yao DouDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Ying WangDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Ting ZengDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Xunzhong QiDepartment of Neurology, the First Affiliated Hospital of Jiamusi University, Jiamusi, China.
Jia-Ning WeiDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Xiao-Wei ShiDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Dan-Dan CuiDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Hui-Zhen DaiDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Chen-Yu DuDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Xiang-Min XuDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Xiao-Fei WangDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Xiaofeng ZhuDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China.
Yanzhong GuanDepartment of Physiology and Neurobiology, Institute of Brain Science, Mudanjiang Medical University, Mudanjiang, China. guanyz@mdjmu.edu.cn.ORCID http://orcid.org/0000-0001-5491-1115

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81871041
6 · The paper itself

Abstract

Cellular and synaptic plasticity in ventral tegmental area (VTA) play a key role in alcohol use disorder (AUD). Here, we first delineated the in vivo dynamics of dopamine (DA) neuron activity in VTA during chronic intermittent ethanol exposure: initial sensitization was followed by a phase of attenuated and dysregulated response upon the first high-concentration exposure, culminating in stable hyper-responsiveness. Chronic ethanol exposure impaired long-term potentiation of GABAergic synapses (LTP

Indexed as

Brain-Derived Neurotrophic FactorLong-Term PotentiationAlcoholismAnimalsDopamineDopaminergic NeuronsEthanolGABAergic Neuronsgamma-Aminobutyric AcidMaleMiceMice, Inbred C57BLNeuronal PlasticityReceptor, trkBRewardSynapsesBrain-Derived Neurotrophic FactorDopamineEthanolgamma-Aminobutyric AcidReceptor, trkB

Identifiers

PMID41872517
PMCPMC13269129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.