Evidence map›Paper›PMID 41872507›Full record

ArticleNature immunology2026

Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200

Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Yuji Nishimura, Takeshi Iwasaki, Shohei Hori, Hiroshi Kawamoto, Hiroki Kato, Gen Kondoh, Akio Morinobu and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yusuke TakeuchiLaboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-2491-9524
Daiya OharaLaboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0009-0004-7946-6352
Hitomi WatanabeLaboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Yuji NishimuraLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Takeshi IwasakiThe Jackson Laboratory, Bar Harbor, ME, USA.
Shohei HoriLaboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-8770-4593
Hiroshi KawamotoLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-7670-9900
Hiroki KatoInstitute of Cardiovascular Immunology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-9571-4895
Gen KondohLaboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Akio MorinobuDepartment of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tsuneyo MimoriDepartment of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Keiji HirotaLaboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. hkeiji@infront.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-4737-0661

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 19H01026
6 · The paper itself

Abstract

Excessive activation of interleukin-17-producing helper T (T

Indexed as

Arthritis, ExperimentalEarly Growth Response Protein 2Receptors, Antigen, T-CellTh17 CellsT-Lymphocytes, RegulatoryAnimalsAntigens, CDCell DifferentiationIntegrin alpha ChainsJointsMiceMice, Inbred C57BLMice, KnockoutSignal Transductionalpha E integrinsAntigens, CDantigens, CD200Early Growth Response Protein 2Egr2 protein, mouseIntegrin alpha ChainsReceptors, Antigen, T-Cell

Identifiers

PMID41872507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.