ArticleNature genetics2026
Single-cell spatial transcriptomic analysis of human skin anatomy.
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Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
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Who cites it
13 citing papers in PubMed.
- mRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation.Experimental dermatology · 2026Review
- A single-cell RNA-seq dataset characterizing cellular diversity in healthy equine skin.Scientific data · 2026Article
- Long-Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Towards 3D-oid models that integrate molecular, morphological and spatial cellular features.Nature reviews. Molecular cell biology · 2026Article
- Single-cell transcriptomics reveals epithelial-stromal crosstalk underlying fibrotic remodeling in frontal fibrosing alopecia.iScience · 2026Article
- Histological and Strand-Specific Transcriptomic Analyses Reveal Developmental Dynamics and Pigmentation-Associated Candidate Genes in Black and White Skin Regions of Bama Miniature Pigs.Animals : an open access journal from MDPI · 2026Article
- Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.Cell communication and signaling : CCS · 2026Review
- Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine axis-mediated recruitment of leukocytes that drive disease.Scientific reports · 2026Article
- Review
- A refined blueprint for human skin.Nature genetics · 2026Article
- Patches: A Representation Learning Framework for Decoding Shared and Condition-Specific Transcriptional Programs in Wound Healing.bioRxiv : the preprint server for biology · 2026Article
- Immunoengineering in the field of tendon and bone regeneration: immunomodulatory biomaterials, delivery platforms, and preclinical models for chronic diseases.Frontiers in bioengineering and biotechnology · 2026Review
- Immune-dominated cellular heterogeneity and stromal plasticity in keloid infiltrating and hypercellular zones revealed by single-cell RNA sequencing.Frontiers in immunology · 2026Article
Corrections and comments
- Update of
Authors and funding
25 authors.
Paula RestrepoGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0003-2045-2357
Alexis WilderBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0009-0005-7789-2689
Aubrey HouserGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Harkirat Singh SandhuBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Angie RamirezTisch Cancer Institute Bioinformatics for Next Generation Sequencing Core, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
M Grace HrenBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Raman GillGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Abiha KazmiBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Larry ChenBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Alexandra NigroBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Ichiro ImanishiBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0002-4292-5533
Deniz DemirciogluTisch Cancer Institute Bioinformatics for Next Generation Sequencing Core, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0001-7857-0407
Dan HassonBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Alan SotoDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Stephanie McQuillanDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Edgar Gonzalez-KozlovaTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0002-6948-0626
Rachel BrodyDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Benjamin UngarKimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Maria KasperDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Catherine P LuThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York City, NY, USA.
Philip TorinaDepartment of Plastic Surgery, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Jesse M LewinKimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Sacha GnjaticTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Sai MaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0002-9785-7929
Andrew L JiBlack Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. andrew.ji@mssm.edu.ORCID http://orcid.org/0000-0001-9688-5680
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MTHE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4MSkin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2MCOVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MCancer Cell-Extrinsic and Intrinsic Regulators of TumorigenesisK08CA263187 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JI, ANDREW · 2021 to 2025
$1.1MResearch Training in Systems Skin BiologyT32AR082315 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Patrick Brunner, Sarah E. Millar · 2023 to 2026
$1.0MDamon Runyon Cancer Research Foundation (Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation) 121-23NCATS NIH HHS UL1 TR004419NCI NIH HHS K08 CA263187NCI NIH HHS P30 CA196521NIAMS NIH HHS P30 AR079200NIAMS NIH HHS T32 AR082315NIH HHS S10 OD026880NIH HHS S10 OD030463U.S. Department of Health & Human Services | National Institutes of Health (NIH) K08CA263187U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30AR079200U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30CA196521U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32AR082315
Abstract
The skin is the largest human organ and a site of substantial disease burden, yet its cellular and molecular organization across the body is largely undefined. Here we construct an organ-wide single-cell spatial atlas of ~1.2 million cells from normal adult human skin, resolving the location of 45 cell types across 114 samples encompassing 15 anatomic sites. We uncover site-specific stereotypic cell-type composition and their organization into ten multicellular neighborhoods, most notably a perivascular neighborhood reminiscent of skin-associated lymphoid tissue. Within this neighborhood, ligand-receptor (L-R) analyses identify a central role for tumor necrosis factor in maintaining CCL19
Indexed as
Single-Cell AnalysisSkinTranscriptomeAdultFibroblastsGene Expression ProfilingHumansSingle-Cell Gene Expression AnalysisSkin DiseasesSpatial Transcriptomics
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.